{"id":4830,"date":"2025-06-04T07:49:44","date_gmt":"2025-06-04T06:49:44","guid":{"rendered":"https:\/\/cbmeds.in\/?post_type=product&p=4830"},"modified":"2025-06-04T07:49:44","modified_gmt":"2025-06-04T06:49:44","slug":"exkivity-40-mg-capsule-mobocertinib","status":"publish","type":"product","link":"https:\/\/cbmeds.in\/?product=exkivity-40-mg-capsule-mobocertinib","title":{"rendered":"EXKIVITY 40 MG CAPSULE ( MOBOCERTINIB )"},"content":{"rendered":"

What is Exkivity?<\/h2>\n

Exkivity (mobocertinib<\/a>) is a tyrosine kinase inhibitor (TKI) used to treat\u00a0non-small cell lung cancer<\/a>\u00a0(NSCLC) that has a specific EGFR gene mutation. Exkivity reduces the growth of non-small cell lung cancer by binding to and inhibiting EGFR exon 20 insertion mutations.<\/p>\n

Exkivity capsules can be used by adults with non-small cell lung cancer that has spread to other parts of the body (metastatic) and cannot be removed with surgery, whose disease has worsened while on or after chemotherapy with platinum, and has cancer has epidermal growth factor receptor (EGFR) exon 20 insertion mutation.<\/p>\n

How does Exkivity work?<\/h2>\n

Epidermal growth factor receptor (EGFR) is a protein that helps cells to grow and divide. \u00a0When EGFR has an exon 20 insertion mutation, it drives cells to grow and divide abnormally, causing an EGFR-positive cancer.\u00a0 Exkivity works by binding to and blocking EGFR exon 20 insertion mutations, which helps to slow the growth of cancer cells.<\/p>\n

What is EXKIVITY Used For?<\/strong><\/h3>\n

EXKIVITY is used for the treatment of:<\/p>\n

\u2705 Non-Small Cell Lung Cancer (NSCLC)<\/strong>
\u2705 In adult patients with EGFR exon 20 insertion mutations<\/strong>
\u2705 Specifically for metastatic NSCLC<\/strong> that has progressed on or after platinum-based chemotherapy<\/strong><\/p>\n

\n

Mechanism of Action:<\/strong><\/h3>\n

Mobocertinib is a tyrosine kinase inhibitor (TKI)<\/strong> designed to specifically target EGFR exon 20 insertion mutations<\/strong>, inhibiting abnormal cell signaling and growth.<\/p>\n

\n

Administration:<\/strong><\/h3>\n
    \n
  • \n

    Oral, once daily<\/strong> (usually 160 mg \u2014 4 capsules of 40 mg each)<\/p>\n<\/li>\n

  • \n

    Taken on an empty stomach<\/strong> (at least 1 hour before or 2 hours after eating)<\/p>\n<\/li>\n<\/ul>\n

    \n

    Common Side Effects:<\/strong><\/h3>\n
      \n
    • \n

      Diarrhea (very common)<\/p>\n<\/li>\n

    • \n

      Rash<\/p>\n<\/li>\n

    • \n

      Nausea<\/p>\n<\/li>\n

    • \n

      Vomiting<\/p>\n<\/li>\n

    • \n

      Fatigue<\/p>\n<\/li>\n

    • \n

      Stomatitis<\/p>\n<\/li>\n

    • \n

      Loss of appetite<\/p>\n<\/li>\n

    • \n

      QT prolongation (requires ECG monitoring)<\/p>\n<\/li>\n<\/ul>\n

      \n

      Warnings:<\/strong><\/h3>\n
        \n
      • \n

        Monitor heart function<\/strong> (ECG, electrolytes)<\/p>\n<\/li>\n

      • \n

        Liver enzymes<\/strong> and pulmonary symptoms<\/strong> should also be regularly checked<\/p>\n<\/li>\n

      • \n

        May cause severe diarrhea<\/strong> \u2014 supportive care may be required<\/p>\n<\/li>\n<\/ul>\n

        \n

        Approval Status:<\/strong><\/h3>\n
          \n
        • \n

          Received accelerated approval<\/strong> from the U.S. FDA<\/strong> for this rare mutation type<\/p>\n<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

          Brand Name:<\/strong> EXKIVITY<\/h3>\n

          Generic Name:<\/strong> Mobocertinib<\/strong><\/h3>\n

          Strength:<\/strong> 40 mg capsules<\/h3>\n

          Form:<\/strong> Oral capsule<\/h3>\n

          Manufacturer:<\/strong> Takeda Pharmaceuticals<\/strong><\/h3>\n","protected":false},"featured_media":4831,"comment_status":"open","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[31],"product_tag":[],"class_list":{"0":"post-4830","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-lung-cancer","7":"desktop-align-left","8":"tablet-align-left","9":"mobile-align-left","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-simple"},"yoast_head":"\nEXKIVITY 40 MG CAPSULE ( MOBOCERTINIB ) - 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