{"id":4833,"date":"2025-06-04T08:14:35","date_gmt":"2025-06-04T07:14:35","guid":{"rendered":"https:\/\/cbmeds.in\/?post_type=product&p=4833"},"modified":"2025-06-04T08:14:35","modified_gmt":"2025-06-04T07:14:35","slug":"pemazyre-4-5mg-9mg-13-5-mg-tab-pemigatinib","status":"publish","type":"product","link":"https:\/\/cbmeds.in\/?product=pemazyre-4-5mg-9mg-13-5-mg-tab-pemigatinib","title":{"rendered":"PEMAZYRE 4.5MG \/ 9MG \/ 13.5 MG TAB (PEMIGATINIB)"},"content":{"rendered":"

 <\/p>\n

What is PEMAZYRE Used For?<\/strong><\/h3>\n

PEMAZYRE<\/strong> is approved for the treatment of:<\/p>\n

\u2705 Cholangiocarcinoma (bile duct cancer)<\/strong>
\u2013 Locally advanced or metastatic
\u2013 With FGFR2 gene fusion or rearrangement<\/strong>
\u2013 In patients who have already received prior treatment<\/strong><\/p>\n

\n

\ud83d\udd36 PEMAZYRE (Pemigatinib)<\/strong><\/h2>\n
\n
\n\n\n\n\n\n\n\n
Strengths<\/strong><\/th>\nForm<\/strong><\/th>\nColor\/Shape<\/strong><\/th>\nUse<\/strong><\/th>\n<\/tr>\n<\/thead>\n
4.5 mg tablet<\/strong><\/td>\nOral tablet<\/td>\nPale yellow, round<\/td>\nDose adjustment or low-dose cycles<\/td>\n<\/tr>\n
9 mg tablet<\/strong><\/td>\nOral tablet<\/td>\nOrange, round<\/td>\nTitration phase<\/td>\n<\/tr>\n
13.5 mg tablet<\/strong><\/td>\nOral tablet<\/td>\nBlue, oval<\/td>\nStandard dose for most patients<\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n
<\/div>\n<\/div>\n<\/div>\n<\/div>\n
\n

\u2705 Indication:<\/strong><\/h3>\n

Advanced Cholangiocarcinoma (Bile Duct Cancer)<\/strong> with confirmed FGFR2 gene fusion or rearrangement<\/strong> after failure of prior systemic therapy.<\/p>\n

\ud83d\udd2c Note:<\/strong> FGFR2 gene mutation must be confirmed by molecular diagnostics.<\/p>\n

\n

\ud83d\udc8a Dosing Schedule:<\/strong><\/h3>\n
    \n
  • \n

    13.5 mg tablet once daily<\/strong><\/p>\n<\/li>\n

  • \n

    14 days on \/ 7 days off<\/strong> (21-day cycle)<\/p>\n<\/li>\n

  • \n

    May adjust to 9 mg or 4.5 mg if side effects occur<\/p>\n<\/li>\n<\/ul>\n

    \n

    \ud83d\udd2c Mechanism of Action:<\/strong><\/h3>\n

    Blocks FGFR1\/2\/3 receptors<\/strong>, inhibiting tumor growth driven by FGFR mutations (esp. FGFR2 fusion).<\/p>\n

    \n

    \u26a0\ufe0f Monitoring Requirements:<\/strong><\/h3>\n
      \n
    • \n

      Serum phosphate levels<\/p>\n<\/li>\n

    • \n

      Liver & kidney function<\/p>\n<\/li>\n

    • \n

      Eye exams<\/strong> (risk of retinal detachment)<\/p>\n<\/li>\n

    • \n

      Electrolytes<\/p>\n<\/li>\n<\/ul>\n

      \n

      \ud83d\udca1 Common Side Effects:<\/strong><\/h3>\n
      \n
      \n\n\n\n\n\n\n\n\n
      Very Common<\/strong><\/th>\nManageable with monitoring<\/strong><\/th>\n<\/tr>\n<\/thead>\n
      Hyperphosphatemia<\/td>\nEye problems (blurred vision)<\/td>\n<\/tr>\n
      Fatigue<\/td>\nDry mouth & taste alteration<\/td>\n<\/tr>\n
      Hair thinning<\/td>\nDiarrhea \/ Constipation<\/td>\n<\/tr>\n
      Nail changes<\/td>\nStomatitis \/ Mucosal inflammation<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
      \n
      <\/div>\n<\/div>\n<\/div>\n<\/div>\n
      \n

      \ud83c\uddee\ud83c\uddf3 Availability in India (2025)<\/strong><\/h2>\n
      \n
      \n\n\n\n\n\n\n\n
      Strength<\/strong><\/th>\nAvailable Brands (India)<\/strong><\/th>\nForm<\/strong><\/th>\n<\/tr>\n<\/thead>\n
      13.5 mg<\/td>\nPemazyre (Incyte, via import) \/ Zydus Pemgi<\/td>\nTablet<\/td>\n<\/tr>\n
      9 mg<\/td>\nPemazyre (Incyte import) \/ Generic via BDR\/MSN<\/td>\nTablet<\/td>\n<\/tr>\n
      4.5 mg<\/td>\nMostly via original brand (imported)<\/strong><\/td>\nTablet<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

      Brand Name:<\/strong> PEMAZYRE<\/strong><\/h3>\n

      Generic Name:<\/strong> Pemigatinib<\/strong><\/h3>\n

      Strengths:<\/strong> 4.5 mg, 9 mg, 13.5 mg tablets<\/h3>\n

      Form:<\/strong> Oral tablets<\/h3>\n

      Manufacturer:<\/strong> Incyte Corporation<\/strong> (USA)<\/h3>\n

      Type:<\/strong> Targeted anti-cancer therapy<\/strong><\/h3>\n","protected":false},"featured_media":4834,"comment_status":"open","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[81],"product_tag":[],"class_list":{"0":"post-4833","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-cholangiocarcinoma","7":"desktop-align-left","8":"tablet-align-left","9":"mobile-align-left","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-simple"},"yoast_head":"\nPEMAZYRE 4.5MG \/ 9MG \/ 13.5 MG TAB (PEMIGATINIB) - 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