{"id":4841,"date":"2025-06-04T09:00:50","date_gmt":"2025-06-04T08:00:50","guid":{"rendered":"https:\/\/cbmeds.in\/?post_type=product&#038;p=4841"},"modified":"2025-06-04T09:04:54","modified_gmt":"2025-06-04T08:04:54","slug":"retevmo-40mg-80mg-selpercatinib","status":"publish","type":"product","link":"https:\/\/cbmeds.in\/?product=retevmo-40mg-80mg-selpercatinib","title":{"rendered":"RETEVMO 40MG\/ 80MG (SELPERCATINIB)"},"content":{"rendered":"<p data-start=\"0\" data-end=\"150\"><span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Retevmo (generic name: selpercatinib) is a prescription medication developed by Eli Lilly and Company.<\/span> <span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">It is primarily used to treat cancers associated with abnormalities in the RET gene, including certain types of non-small cell lung cancer (NSCLC), medullary thyroid cancer (MTC), and other solid tumors.<\/span> <span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Retevmo functions as a targeted therapy by inhibiting the RET kinase, a protein that contributes to cancer cell growth when mutated or fused.<\/span><\/p>\n<hr data-start=\"152\" data-end=\"155\" \/>\n<h3 data-start=\"157\" data-end=\"176\">\ud83d\udc8a Dosage Forms<\/h3>\n<ul data-start=\"178\" data-end=\"367\">\n<li data-start=\"178\" data-end=\"233\">\n<p data-start=\"180\" data-end=\"233\"><strong data-start=\"180\" data-end=\"192\">Capsules<\/strong>: <span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">40 mg and 80 mg<\/span><\/p>\n<\/li>\n<li data-start=\"234\" data-end=\"367\">\n<p data-start=\"236\" data-end=\"367\"><strong data-start=\"236\" data-end=\"247\">Tablets<\/strong>: <span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">40 mg, 80 mg, 120 mg, and 160 mg<\/span><\/p>\n<\/li>\n<\/ul>\n<p data-start=\"369\" data-end=\"488\"><span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">The 80 mg capsule is blue and oblong, imprinted with &#8220;Lilly 2980 80 mg&#8221;<\/span> .<\/p>\n<hr data-start=\"490\" data-end=\"493\" \/>\n<h3 data-start=\"495\" data-end=\"513\">\ud83e\uddec Indications<\/h3>\n<p data-start=\"515\" data-end=\"593\"><span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Retevmo is indicated for:<\/span><\/p>\n<ul data-start=\"595\" data-end=\"1029\">\n<li data-start=\"595\" data-end=\"683\">\n<p data-start=\"597\" data-end=\"683\"><strong data-start=\"597\" data-end=\"643\">Adults and children aged 2 years and older<\/strong> <span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">with advanced or metastatic RET fusion-positive non-small cell lung cancer (NSCLC)<\/span><\/p>\n<\/li>\n<li data-start=\"684\" data-end=\"772\">\n<p data-start=\"686\" data-end=\"772\"><strong data-start=\"686\" data-end=\"732\">Adults and children aged 2 years and older<\/strong> <span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">with advanced or metastatic RET mutation-positive medullary thyroid cancer (MTC)<\/span><\/p>\n<\/li>\n<li data-start=\"773\" data-end=\"861\">\n<p data-start=\"775\" data-end=\"861\"><strong data-start=\"775\" data-end=\"821\">Adults and children aged 2 years and older<\/strong> <span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">with advanced or metastatic RET fusion-positive thyroid cancer who require systemic therapy and are refractory to radioactive iodine<\/span><\/p>\n<\/li>\n<li data-start=\"862\" data-end=\"1029\">\n<p data-start=\"864\" data-end=\"1029\"><strong data-start=\"864\" data-end=\"910\">Adults and children aged 2 years and older<\/strong> <span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">with locally advanced or metastatic solid tumors harboring a RET gene fusion that have progressed on or following prior systemic treatments or have no satisfactory alternative treatment options<\/span><\/p>\n<\/li>\n<\/ul>\n<hr data-start=\"1031\" data-end=\"1034\" \/>\n<h3 data-start=\"1036\" data-end=\"1060\">\u2696\ufe0f Dosage Guidelines<\/h3>\n<p data-start=\"1062\" data-end=\"1140\"><span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">The recommended dosage varies based on age, weight, and body surface area (BSA):<\/span><\/p>\n<p data-start=\"1062\" data-end=\"1140\"><strong data-start=\"1144\" data-end=\"1183\">\u00a0 Adults and adolescents (\u226512 years):<\/strong><\/p>\n<ul data-start=\"1142\" data-end=\"1649\">\n<li style=\"list-style-type: none;\" data-start=\"1142\" data-end=\"1350\">\n<ul data-start=\"1186\" data-end=\"1350\">\n<li data-start=\"1186\" data-end=\"1227\">\n<p data-start=\"1188\" data-end=\"1227\"><span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Weighing \u226550 kg: 160 mg orally twice daily<\/span><\/p>\n<\/li>\n<li data-start=\"1230\" data-end=\"1350\">\n<p data-start=\"1232\" data-end=\"1350\"><span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Weighing &lt;50 kg: 120 mg orally twice daily<\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<li data-start=\"1352\" data-end=\"1649\">\n<p data-start=\"1354\" data-end=\"1394\"><strong data-start=\"1354\" data-end=\"1394\">Pediatric patients (2 to &lt;12 years):<\/strong><\/p>\n<ul data-start=\"1397\" data-end=\"1649\">\n<li data-start=\"1397\" data-end=\"1438\">\n<p data-start=\"1399\" data-end=\"1438\"><span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">BSA 0.33\u20130.65 m\u00b2: 40 mg orally three times daily<\/span><\/p>\n<\/li>\n<li data-start=\"1441\" data-end=\"1482\">\n<p data-start=\"1443\" data-end=\"1482\"><span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">BSA 0.66\u20131.08 m\u00b2: 80 mg orally twice daily<\/span><\/p>\n<\/li>\n<li data-start=\"1485\" data-end=\"1526\">\n<p data-start=\"1487\" data-end=\"1526\"><span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">BSA 1.09\u20131.52 m\u00b2: 120 mg orally twice daily<\/span><\/p>\n<\/li>\n<li data-start=\"1529\" data-end=\"1649\">\n<p data-start=\"1531\" data-end=\"1649\"><span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">BSA \u22651.53 m\u00b2: 160 mg orally twice daily<\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p data-start=\"1651\" data-end=\"1770\"><span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Dosage adjustments may be necessary in cases of hepatic impairment or when coadministered with strong CYP3A inhibitors<\/span> .<\/p>\n<hr data-start=\"1772\" data-end=\"1775\" \/>\n<h3 data-start=\"1777\" data-end=\"1796\">\u26a0\ufe0f Side Effects<\/h3>\n<p data-start=\"1798\" data-end=\"1834\"><strong data-start=\"1798\" data-end=\"1821\">Common side effects<\/strong> may include:<\/p>\n<ul data-start=\"1836\" data-end=\"1956\">\n<li data-start=\"1836\" data-end=\"1956\">\n<p data-start=\"1838\" data-end=\"1956\"><span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Edema (swelling), diarrhea, fatigue, dry mouth, abdominal pain, constipation, rash, nausea, and headache<\/span><\/p>\n<\/li>\n<\/ul>\n<p data-start=\"1958\" data-end=\"1995\"><strong data-start=\"1958\" data-end=\"1982\">Serious side effects<\/strong> may include:<\/p>\n<ul data-start=\"1997\" data-end=\"2503\">\n<li data-start=\"1997\" data-end=\"2038\">\n<p data-start=\"1999\" data-end=\"2038\"><span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Liver problems (e.g., jaundice, dark urine, nausea)<\/span><\/p>\n<\/li>\n<li data-start=\"2039\" data-end=\"2080\">\n<p data-start=\"2041\" data-end=\"2080\"><span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Lung issues (e.g., shortness of breath, cough, fever)<\/span><\/p>\n<\/li>\n<li data-start=\"2081\" data-end=\"2122\">\n<p data-start=\"2083\" data-end=\"2122\"><span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">High blood pressure<\/span><\/p>\n<\/li>\n<li data-start=\"2123\" data-end=\"2164\">\n<p data-start=\"2125\" data-end=\"2164\"><span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Heart rhythm changes (QT prolongation)<\/span><\/p>\n<\/li>\n<li data-start=\"2165\" data-end=\"2206\">\n<p data-start=\"2167\" data-end=\"2206\"><span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Bleeding problems<\/span><\/p>\n<\/li>\n<li data-start=\"2207\" data-end=\"2248\">\n<p data-start=\"2209\" data-end=\"2248\"><span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Allergic reactions<\/span><\/p>\n<\/li>\n<li data-start=\"2249\" data-end=\"2290\">\n<p data-start=\"2251\" data-end=\"2290\"><span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Tumor lysis syndrome (TLS)<\/span><\/p>\n<\/li>\n<li data-start=\"2291\" data-end=\"2332\">\n<p data-start=\"2293\" data-end=\"2332\"><span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Wound healing issues<\/span><\/p>\n<\/li>\n<li data-start=\"2333\" data-end=\"2376\">\n<p data-start=\"2335\" data-end=\"2376\"><span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Thyroid hormone imbalances<\/span><\/p>\n<\/li>\n<li data-start=\"2377\" data-end=\"2503\">\n<p data-start=\"2379\" data-end=\"2503\"><span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Hip joint problems in children<\/span><\/p>\n<\/li>\n<\/ul>\n<p data-start=\"2505\" data-end=\"2587\"><span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Regular monitoring through blood tests and clinical assessments is recommended during treatment.<\/span><\/p>\n<hr data-start=\"2589\" data-end=\"2592\" \/>\n<h3 data-start=\"2594\" data-end=\"2625\">\u26a0\ufe0f Warnings and Precautions<\/h3>\n<ul data-start=\"2627\" data-end=\"3349\">\n<li data-start=\"2627\" data-end=\"2690\">\n<p data-start=\"2629\" data-end=\"2690\"><strong data-start=\"2629\" data-end=\"2647\">Liver Function<\/strong>: <span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Monitor liver enzymes regularly; withhold or discontinue treatment if significant abnormalities occur.<\/span><\/p>\n<\/li>\n<li data-start=\"2691\" data-end=\"2751\">\n<p data-start=\"2693\" data-end=\"2751\"><strong data-start=\"2693\" data-end=\"2708\">Lung Health<\/strong>: <span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Be vigilant for signs of interstitial lung disease or pneumonitis; immediate medical attention is required if symptoms develop.<\/span><\/p>\n<\/li>\n<li data-start=\"2752\" data-end=\"2815\">\n<p data-start=\"2754\" data-end=\"2815\"><strong data-start=\"2754\" data-end=\"2772\">Blood Pressure<\/strong>: <span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Regularly check blood pressure; manage hypertension as needed.<\/span><\/p>\n<\/li>\n<li data-start=\"2816\" data-end=\"2877\">\n<p data-start=\"2818\" data-end=\"2877\"><strong data-start=\"2818\" data-end=\"2834\">Heart Rhythm<\/strong>: <span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Electrocardiogram (ECG) monitoring may be necessary due to potential QT prolongation.<\/span><\/p>\n<\/li>\n<li data-start=\"2878\" data-end=\"2940\">\n<p data-start=\"2880\" data-end=\"2940\"><strong data-start=\"2880\" data-end=\"2897\">Bleeding Risk<\/strong>: <span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Exercise caution in patients with bleeding disorders.<\/span><\/p>\n<\/li>\n<li data-start=\"2941\" data-end=\"3008\">\n<p data-start=\"2943\" data-end=\"3008\"><strong data-start=\"2943\" data-end=\"2965\">Allergic Reactions<\/strong>: <span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Discontinue if severe reactions occur.<\/span><\/p>\n<\/li>\n<li data-start=\"3009\" data-end=\"3078\">\n<p data-start=\"3011\" data-end=\"3078\"><strong data-start=\"3011\" data-end=\"3035\">Tumor Lysis Syndrome<\/strong>: <span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Stay well-hydrated and monitor for symptoms.<\/span><\/p>\n<\/li>\n<li data-start=\"3079\" data-end=\"3141\">\n<p data-start=\"3081\" data-end=\"3141\"><strong data-start=\"3081\" data-end=\"3098\">Wound Healing<\/strong>: <span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Discontinue at least 7 days before planned surgery; consult healthcare provider for resumption.<\/span><\/p>\n<\/li>\n<li data-start=\"3142\" data-end=\"3207\">\n<p data-start=\"3144\" data-end=\"3207\"><strong data-start=\"3144\" data-end=\"3164\">Thyroid Function<\/strong>: <span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Monitor thyroid hormone levels; adjust treatment as necessary.<\/span><\/p>\n<\/li>\n<li data-start=\"3208\" data-end=\"3349\">\n<p data-start=\"3210\" data-end=\"3349\"><strong data-start=\"3210\" data-end=\"3223\">Pregnancy<\/strong>: <span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Avoid use during pregnancy; may harm the fetus.<\/span><\/p>\n<\/li>\n<\/ul>\n<hr data-start=\"3351\" data-end=\"3354\" \/>\n<h3 data-start=\"3356\" data-end=\"3378\">\ud83d\udccc Important Notes<\/h3>\n<ul data-start=\"3380\" data-end=\"3731\">\n<li data-start=\"3380\" data-end=\"3443\">\n<p data-start=\"3382\" data-end=\"3443\"><strong data-start=\"3382\" data-end=\"3400\">Administration<\/strong>: <span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Take Retevmo orally, with or without food.<\/span><\/p>\n<\/li>\n<li data-start=\"3444\" data-end=\"3504\">\n<p data-start=\"3446\" data-end=\"3504\"><strong data-start=\"3446\" data-end=\"3461\">Missed Dose<\/strong>: <span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">If a dose is missed, take it as soon as remembered unless it&#8217;s close to the time for the next dose; do not double doses.<\/span><\/p>\n<\/li>\n<li data-start=\"3505\" data-end=\"3571\">\n<p data-start=\"3507\" data-end=\"3571\"><strong data-start=\"3507\" data-end=\"3528\">Drug Interactions<\/strong>: <span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Inform healthcare providers of all medications being taken, including over-the-counter drugs and supplements.<\/span><\/p>\n<\/li>\n<li data-start=\"3572\" data-end=\"3630\">\n<p data-start=\"3574\" data-end=\"3630\"><strong data-start=\"3574\" data-end=\"3587\">Fertility<\/strong>: <span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">May affect fertility; discuss concerns with a healthcare provider.<\/span><\/p>\n<\/li>\n<li data-start=\"3631\" data-end=\"3731\">\n<p data-start=\"3633\" data-end=\"3731\"><strong data-start=\"3633\" data-end=\"3647\">Monitoring<\/strong>: <span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Regular follow-up appointments are essential to assess treatment efficacy and manage potential side effects<\/span><\/p>\n<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<h4><strong>\ud83d\udd39 GENERIC NAME : SELPERCATINIB<\/strong><br \/>\n<strong>\ud83d\udc8a DRUG CLASS : RET KINASE INHIBITOR<\/strong><br \/>\n<strong>\ud83e\uddec TARGET : RET FUSION-POSITIVE OR RET-MUTANT CANCERS<\/strong><br \/>\n<strong>\ud83c\udfed ORIGINAL BRAND : RETEVMO<\/strong><br \/>\n<strong>\u00a0 \u00a0 \u00a0 \u00a0MANUFACTURER : ELI LILLY (USA)<\/strong><\/h4>\n","protected":false},"featured_media":4842,"comment_status":"open","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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