eczema<\/a>\u00a0(atopic dermatitis) that is moderate to severe in patients who have not found relief with topical medications or are not able to use them. Cibinqo is a once-a-day tablet that can be used by adults and children over 12 years of age.\u00a0Eczema may be caused by an overactive immune system leading to inflammation which causes dry, itchy skin and eczema flare-ups. Janus kinase (JAK) is an enzyme thought to play a role in skin inflammation. Cibinqo works by blocking the JAK1 activity, decreasing inflammation which helps reduce itching and improves skin condition.<\/p>\nCIBINQO\u00ae (abrocitinib)<\/strong> is an oral medication approved for the treatment of moderate-to-severe atopic dermatitis (eczema) in adults and adolescents aged 12 years and older.<\/span> It is particularly indicated for patients whose condition is not adequately controlled with other systemic therapies, including biologics, or when such treatments are inadvisable.<\/span><\/p>\n\ud83d\udd2c Mechanism of Action<\/h3>\n
CIBINQO is a selective Janus kinase 1 (JAK1) inhibitor.<\/span> By inhibiting JAK1, it disrupts the signaling pathways of various pro-inflammatory cytokines involved in the pathogenesis of atopic dermatitis, leading to reduced inflammation and alleviation of symptoms such as itching.<\/span><\/p>\n
\n\ud83d\udc8a Dosage and Administration<\/h3>\n\n- \n
Recommended Starting Dose<\/strong>: 100 mg taken orally once daily.<\/span><\/p>\n<\/li>\n- \n
Dose Adjustment<\/strong>: If the response is inadequate after 12 weeks, the dose may be increased to 200 mg once daily.<\/span><\/p>\n<\/li>\n- \n
Dose Reduction<\/strong>: In patients with moderate renal impairment or when co-administered with strong CYP2C19 inhibitors, a starting dose of 50 mg once daily is recommended.<\/span><\/p>\n<\/li>\n- \n
Administration<\/strong>: CIBINQO can be taken with or without food.<\/span><\/p>\n<\/li>\n<\/ul>\n
\n\u2705 Efficacy<\/h3>\n
Clinical trials have demonstrated that CIBINQO provides significant improvements in skin clearance and itch relief<\/span><\/p>\n\n- \n
At 12 weeks, 41% of patients taking 200 mg and 26% taking 100 mg achieved clear or almost clear skin, compared to 8% with placebo.<\/span><\/p>\n<\/li>\n- \n
Rapid itch reduction was observed as early as week 2 in some patients.<\/span><\/p>\n<\/li>\n<\/ul>\n
\n\u26a0\ufe0f Safety and Side Effects<\/h3>\n
Common Side Effects<\/strong>:<\/p>\n\n- \n
Nausea<\/span><\/p>\n<\/li>\n- \n
Headache<\/span><\/p>\n<\/li>\n- \n
Acne<\/p>\n<\/li>\n
- \n
Herpes simplex infections (e.g., cold sores)<\/span><\/p>\n<\/li>\n- \n
Increased blood levels of creatine phosphokinase<\/span><\/p>\n<\/li>\n- \n
Dizziness<\/span><\/p>\n<\/li>\n- \n
Upper abdominal pain<\/span><\/p>\n<\/li>\n<\/ul>\nSerious Risks<\/strong>:<\/p>\n\n- \n
Serious infections (e.g., tuberculosis, herpes zoster)<\/span><\/p>\n<\/li>\n- \n
Major adverse cardiovascular events (MACE)<\/span><\/p>\n<\/li>\n- \n
Thrombosis (blood clots)<\/span><\/p>\n<\/li>\n- \n
Malignancies<\/span><\/p>\n<\/li>\n- \n
Laboratory abnormalities (e.g., thrombocytopenia, lymphopenia, lipid elevations)<\/span><\/p>\n<\/li>\n<\/ul>\nMonitoring<\/strong>:<\/p>\n\n- \n
Prior to initiating therapy, patients should be evaluated for tuberculosis and other infections.<\/span><\/p>\n<\/li>\n- \n
Regular monitoring of blood counts, liver enzymes, and lipid profiles is recommended during treatment.<\/span><\/p>\n<\/li>\n<\/ul>\n <\/p>\n","protected":false},"excerpt":{"rendered":"
\n- \n
Brand Name<\/strong>: CIBINQO<\/span><\/p>\n<\/li>\n- \n
Generic Name<\/strong>: Abrocitinib<\/span><\/p>\n<\/li>\n- \n
Manufacturer<\/strong>: Pfizer Inc.<\/span><\/p>\n<\/li>\n- \n
Formulation<\/strong>: Film-coated oral tablets<\/span><\/p>\n<\/li>\n- \n
Available Strengths<\/strong>: 50 mg, 100 mg, and 200 mg<\/span><\/p>\n<\/li>\n- \n
Composition<\/strong>:<\/p>\n\n- \n
Active Ingredient<\/strong>: Abrocitinib<\/span><\/p>\n<\/li>\n- \n
Inactive Ingredients<\/strong>: Microcrystalline cellulose, anhydrous dibasic calcium phosphate, sodium starch glycolate, magnesium stearate, hypromellose, titanium dioxide, lactose monohydrate, polyethylene glycol, triacetin, and ferric oxide red<\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n","protected":false},"featured_media":4859,"comment_status":"open","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[16],"product_tag":[],"class_list":{"0":"post-4858","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-uncategorised","7":"desktop-align-left","8":"tablet-align-left","9":"mobile-align-left","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-simple"},"yoast_head":"\nCIBINQO 100 MG TAB (ABROCITINIB) - Curiance Biotech<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cbmeds.in\/?product=cibinqo-100-mg-tab-abrocitinib\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CIBINQO 100 MG TAB (ABROCITINIB) - Curiance Biotech\" \/>\n<meta property=\"og:description\" content=\"Brand Name: CIBINQO Generic Name: Abrocitinib Manufacturer: Pfizer Inc. 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