{"id":4899,"date":"2025-06-06T06:56:36","date_gmt":"2025-06-06T05:56:36","guid":{"rendered":"https:\/\/cbmeds.in\/?post_type=product&#038;p=4899"},"modified":"2025-06-06T06:56:36","modified_gmt":"2025-06-06T05:56:36","slug":"tibsovo-250-mg-tab-ivosidenib","status":"publish","type":"product","link":"https:\/\/cbmeds.in\/?product=tibsovo-250-mg-tab-ivosidenib","title":{"rendered":"TIBSOVO 250 MG TAB (IVOSIDENIB)"},"content":{"rendered":"<h2 id=\"uses\" class=\"ddc-anchor-offset\">What is Tibsovo?<\/h2>\n<p>Tibsovo (ivosidenib) is a once-daily oral medication that targets a specific gene mutation called the isocitrate dehydrogenase-1 (IDH1) mutation, which can affect your bone marrow. An IDH1 mutation prevents young blood cells from developing into healthy adult blood cells, which can result in blood and bone marrow disorders such as acute myeloid leukemia (AML).<\/p>\n<p>Tibsovo may be used to treat adults with a confirmed susceptible IDH1 mutation with:<\/p>\n<ul>\n<li>newly diagnosed acute myeloid leukemia (AML) either in combination with azacitidine or as monotherapy in patients 75 years or older who have comorbidities that preclude the use of intensive induction chemotherapy<\/li>\n<li>relapsed or refractory AML<\/li>\n<li>relapsed or refractory myelodysplastic syndromes<\/li>\n<li>bile duct cancer (cholangiocarcinoma) that has progressed or has spread to other parts of the body (metastatic) after treatment with other medicine.<\/li>\n<\/ul>\n<h3 data-start=\"89\" data-end=\"112\">\ud83e\uddec <strong data-start=\"96\" data-end=\"112\">Introduction<\/strong><\/h3>\n<p data-start=\"114\" data-end=\"538\"><strong data-start=\"114\" data-end=\"128\">Ivosidenib<\/strong> (brand name: <strong data-start=\"142\" data-end=\"154\">Tibsovo\u00ae<\/strong>) is an <strong data-start=\"162\" data-end=\"201\">oral targeted anticancer medication<\/strong> developed to treat cancers with a specific genetic mutation in the <strong data-start=\"269\" data-end=\"306\">IDH1 (isocitrate dehydrogenase 1)<\/strong> gene. This mutation leads to abnormal cell growth. Ivosidenib is <strong data-start=\"372\" data-end=\"409\">the first-in-class IDH1 inhibitor<\/strong>, and it provides a precision treatment option in <strong data-start=\"459\" data-end=\"491\">acute myeloid leukemia (AML)<\/strong> and <strong data-start=\"496\" data-end=\"537\">cholangiocarcinoma (bile duct cancer)<\/strong>.<\/p>\n<hr data-start=\"540\" data-end=\"543\" \/>\n<h3 data-start=\"545\" data-end=\"572\">\ud83d\udc8a <strong data-start=\"552\" data-end=\"572\">Salt\/Composition<\/strong><\/h3>\n<ul data-start=\"574\" data-end=\"768\">\n<li data-start=\"574\" data-end=\"606\">\n<p data-start=\"576\" data-end=\"606\"><strong data-start=\"576\" data-end=\"592\">Generic Name<\/strong>: Ivosidenib<\/p>\n<\/li>\n<li data-start=\"607\" data-end=\"635\">\n<p data-start=\"609\" data-end=\"635\"><strong data-start=\"609\" data-end=\"623\">Brand Name<\/strong>: Tibsovo<\/p>\n<\/li>\n<li data-start=\"636\" data-end=\"656\">\n<p data-start=\"638\" data-end=\"656\"><strong data-start=\"638\" data-end=\"646\">Form<\/strong>: Tablet<\/p>\n<\/li>\n<li data-start=\"657\" data-end=\"681\">\n<p data-start=\"659\" data-end=\"681\"><strong data-start=\"659\" data-end=\"671\">Strength<\/strong>: 250 mg<\/p>\n<\/li>\n<li data-start=\"682\" data-end=\"768\">\n<p data-start=\"684\" data-end=\"768\"><strong data-start=\"684\" data-end=\"709\">Manufacturer in India<\/strong>: Servier India (via global parent Servier Pharmaceuticals)<\/p>\n<\/li>\n<\/ul>\n<hr data-start=\"770\" data-end=\"773\" \/>\n<h3 data-start=\"775\" data-end=\"804\">\ud83d\udccb <strong data-start=\"782\" data-end=\"804\">Uses \/ Indications<\/strong><\/h3>\n<p data-start=\"806\" data-end=\"895\">Ivosidenib is used in patients who test positive for <strong data-start=\"859\" data-end=\"876\">IDH1 mutation<\/strong> for the following:<\/p>\n<ol data-start=\"897\" data-end=\"1225\">\n<li data-start=\"897\" data-end=\"955\">\n<p data-start=\"900\" data-end=\"955\"><strong data-start=\"900\" data-end=\"955\">Relapsed or refractory Acute Myeloid Leukemia (AML)<\/strong><\/p>\n<\/li>\n<li data-start=\"956\" data-end=\"1077\">\n<p data-start=\"959\" data-end=\"1077\"><strong data-start=\"959\" data-end=\"982\">Newly diagnosed AML<\/strong> in adults who are 75 years or older or have comorbidities that preclude intensive chemotherapy<\/p>\n<\/li>\n<li data-start=\"1078\" data-end=\"1225\">\n<p data-start=\"1081\" data-end=\"1225\"><strong data-start=\"1081\" data-end=\"1103\">Cholangiocarcinoma<\/strong> (bile duct cancer) that is locally advanced or metastatic and has been treated with at least one previous line of therapy<\/p>\n<\/li>\n<\/ol>\n<hr data-start=\"1227\" data-end=\"1230\" \/>\n<h3 data-start=\"1232\" data-end=\"1268\">\ud83e\uddea <strong data-start=\"1239\" data-end=\"1268\">Dosage and Administration<\/strong><\/h3>\n<ul data-start=\"1270\" data-end=\"1547\">\n<li data-start=\"1270\" data-end=\"1323\">\n<p data-start=\"1272\" data-end=\"1323\"><strong data-start=\"1272\" data-end=\"1289\">Standard Dose<\/strong>:<br data-start=\"1290\" data-end=\"1293\" \/><strong data-start=\"1295\" data-end=\"1323\">250 mg orally once daily<\/strong><\/p>\n<\/li>\n<li data-start=\"1324\" data-end=\"1404\">\n<p data-start=\"1326\" data-end=\"1404\"><strong data-start=\"1326\" data-end=\"1338\">Duration<\/strong>:<br data-start=\"1339\" data-end=\"1342\" \/>Continue until disease progression or unacceptable toxicity.<\/p>\n<\/li>\n<li data-start=\"1405\" data-end=\"1547\">\n<p data-start=\"1407\" data-end=\"1426\"><strong data-start=\"1407\" data-end=\"1425\">Administration<\/strong>:<\/p>\n<ul data-start=\"1429\" data-end=\"1547\">\n<li data-start=\"1429\" data-end=\"1468\">\n<p data-start=\"1431\" data-end=\"1468\">Can be taken <strong data-start=\"1444\" data-end=\"1468\">with or without food<\/strong><\/p>\n<\/li>\n<li data-start=\"1471\" data-end=\"1517\">\n<p data-start=\"1473\" data-end=\"1517\"><strong data-start=\"1473\" data-end=\"1505\">Do not crush, chew, or split<\/strong> the tablet.<\/p>\n<\/li>\n<li data-start=\"1520\" data-end=\"1547\">\n<p data-start=\"1522\" data-end=\"1547\">Swallow whole with water.<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<hr data-start=\"1549\" data-end=\"1552\" \/>\n<h3 data-start=\"1554\" data-end=\"1577\">\u26a0\ufe0f <strong data-start=\"1561\" data-end=\"1577\">Side Effects<\/strong><\/h3>\n<p data-start=\"1579\" data-end=\"1599\">Common side effects:<\/p>\n<ul data-start=\"1600\" data-end=\"1835\">\n<li data-start=\"1600\" data-end=\"1608\">\n<p data-start=\"1602\" data-end=\"1608\">Nausea<\/p>\n<\/li>\n<li data-start=\"1609\" data-end=\"1635\">\n<p data-start=\"1611\" data-end=\"1635\">Diarrhea or constipation<\/p>\n<\/li>\n<li data-start=\"1636\" data-end=\"1645\">\n<p data-start=\"1638\" data-end=\"1645\">Fatigue<\/p>\n<\/li>\n<li data-start=\"1646\" data-end=\"1681\">\n<p data-start=\"1648\" data-end=\"1681\">Increased liver enzymes (AST\/ALT)<\/p>\n<\/li>\n<li data-start=\"1682\" data-end=\"1703\">\n<p data-start=\"1684\" data-end=\"1703\">Shortness of breath<\/p>\n<\/li>\n<li data-start=\"1704\" data-end=\"1716\">\n<p data-start=\"1706\" data-end=\"1716\">Joint pain<\/p>\n<\/li>\n<li data-start=\"1717\" data-end=\"1762\">\n<p data-start=\"1719\" data-end=\"1762\">Prolonged QT interval (heart rhythm change)<\/p>\n<\/li>\n<li data-start=\"1763\" data-end=\"1791\">\n<p data-start=\"1765\" data-end=\"1791\">Low potassium or magnesium<\/p>\n<\/li>\n<li data-start=\"1792\" data-end=\"1835\">\n<p data-start=\"1794\" data-end=\"1835\">White blood cell differentiation syndrome<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"1837\" data-end=\"1858\">Serious side effects:<\/p>\n<ul data-start=\"1859\" data-end=\"2020\">\n<li data-start=\"1859\" data-end=\"1928\">\n<p data-start=\"1861\" data-end=\"1928\"><strong data-start=\"1861\" data-end=\"1889\">Differentiation Syndrome<\/strong> (can be fatal if not treated promptly)<\/p>\n<\/li>\n<li data-start=\"1929\" data-end=\"1974\">\n<p data-start=\"1931\" data-end=\"1974\"><strong data-start=\"1931\" data-end=\"1956\">Heart rhythm problems<\/strong> (QT prolongation)<\/p>\n<\/li>\n<li data-start=\"1975\" data-end=\"1993\">\n<p data-start=\"1977\" data-end=\"1993\"><strong data-start=\"1977\" data-end=\"1993\">Liver injury<\/strong><\/p>\n<\/li>\n<li data-start=\"1994\" data-end=\"2020\">\n<p data-start=\"1996\" data-end=\"2020\"><strong data-start=\"1996\" data-end=\"2020\">Tumor lysis syndrome<\/strong><\/p>\n<\/li>\n<\/ul>\n<hr data-start=\"2022\" data-end=\"2025\" \/>\n<h3 data-start=\"2027\" data-end=\"2060\">\u26a0\ufe0f <strong data-start=\"2034\" data-end=\"2060\">Precautions &amp; Warnings<\/strong><\/h3>\n<ol data-start=\"2062\" data-end=\"2837\">\n<li data-start=\"2062\" data-end=\"2153\">\n<p data-start=\"2065\" data-end=\"2153\"><strong data-start=\"2065\" data-end=\"2096\">IDH1 Mutation Test Required<\/strong>:<br data-start=\"2097\" data-end=\"2100\" \/>Use only in patients with confirmed IDH1 mutation.<\/p>\n<\/li>\n<li data-start=\"2155\" data-end=\"2319\">\n<p data-start=\"2158\" data-end=\"2201\"><strong data-start=\"2158\" data-end=\"2198\">Avoid in Pregnancy and Breastfeeding<\/strong>:<\/p>\n<ul data-start=\"2205\" data-end=\"2319\">\n<li data-start=\"2205\" data-end=\"2229\">\n<p data-start=\"2207\" data-end=\"2229\">May cause fetal harm<\/p>\n<\/li>\n<li data-start=\"2233\" data-end=\"2319\">\n<p data-start=\"2235\" data-end=\"2319\">Use effective contraception during treatment and for <strong data-start=\"2288\" data-end=\"2319\">1 month after the last dose<\/strong><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<li data-start=\"2321\" data-end=\"2445\">\n<p data-start=\"2324\" data-end=\"2346\"><strong data-start=\"2324\" data-end=\"2343\">QT Prolongation<\/strong>:<\/p>\n<ul data-start=\"2350\" data-end=\"2445\">\n<li data-start=\"2350\" data-end=\"2392\">\n<p data-start=\"2352\" data-end=\"2392\">Monitor ECG and electrolytes regularly<\/p>\n<\/li>\n<li data-start=\"2396\" data-end=\"2445\">\n<p data-start=\"2398\" data-end=\"2445\">Avoid combining with drugs that also prolong QT<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<li data-start=\"2447\" data-end=\"2539\">\n<p data-start=\"2450\" data-end=\"2482\"><strong data-start=\"2450\" data-end=\"2479\">Liver Function Monitoring<\/strong>:<\/p>\n<ul data-start=\"2486\" data-end=\"2539\">\n<li data-start=\"2486\" data-end=\"2539\">\n<p data-start=\"2488\" data-end=\"2539\">Regular LFTs (Liver Function Tests) are recommended<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<li data-start=\"2541\" data-end=\"2620\">\n<p data-start=\"2544\" data-end=\"2573\"><strong data-start=\"2544\" data-end=\"2570\">Avoid Grapefruit Juice<\/strong>:<\/p>\n<ul data-start=\"2577\" data-end=\"2620\">\n<li data-start=\"2577\" data-end=\"2620\">\n<p data-start=\"2579\" data-end=\"2620\">May increase drug levels and side effects<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<li data-start=\"2622\" data-end=\"2837\">\n<p data-start=\"2625\" data-end=\"2656\"><strong data-start=\"2625\" data-end=\"2653\">Differentiation Syndrome<\/strong>:<\/p>\n<ul data-start=\"2660\" data-end=\"2837\">\n<li data-start=\"2660\" data-end=\"2700\">\n<p data-start=\"2662\" data-end=\"2700\">Can appear within the first 3 months<\/p>\n<\/li>\n<li data-start=\"2704\" data-end=\"2791\">\n<p data-start=\"2706\" data-end=\"2791\">Symptoms: fever, cough, low blood pressure, rapid weight gain, breathing difficulty<\/p>\n<\/li>\n<li data-start=\"2795\" data-end=\"2837\">\n<p data-start=\"2797\" data-end=\"2837\">Requires urgent corticosteroid treatment<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n<hr data-start=\"2839\" data-end=\"2842\" \/>\n<h3 data-start=\"2844\" data-end=\"2864\">\u2705 <strong data-start=\"2850\" data-end=\"2864\">Conclusion<\/strong><\/h3>\n<p data-start=\"2866\" data-end=\"3218\"><strong data-start=\"2866\" data-end=\"2891\">Ivosidenib (Tibsovo)<\/strong> is a <strong data-start=\"2897\" data-end=\"2930\">breakthrough targeted therapy<\/strong> for cancers with the IDH1 mutation. It represents a significant step forward for <strong data-start=\"3012\" data-end=\"3034\">precision oncology<\/strong>, especially for patients with limited options.<br data-start=\"3081\" data-end=\"3084\" \/>Regular <strong data-start=\"3092\" data-end=\"3106\">monitoring<\/strong>, <strong data-start=\"3108\" data-end=\"3127\">genetic testing<\/strong>, and <strong data-start=\"3133\" data-end=\"3159\">specialist supervision<\/strong> are essential for safe and effective use of this medicine.<\/p>\n","protected":false},"excerpt":{"rendered":"<h3 data-start=\"81\" data-end=\"125\">\ud83e\uddec <strong data-start=\"88\" data-end=\"125\">Overview of Ivosidenib (Tibsovo)<\/strong><\/h3>\n<ul data-start=\"127\" data-end=\"505\">\n<li data-start=\"127\" data-end=\"184\">\n<p data-start=\"129\" data-end=\"184\"><strong data-start=\"129\" data-end=\"145\">Generic Name<\/strong>: <span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Ivosidenib<\/span><\/p>\n<\/li>\n<li data-start=\"185\" data-end=\"240\">\n<p data-start=\"187\" data-end=\"240\"><strong data-start=\"187\" data-end=\"201\">Brand Name<\/strong>: <span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Tibsovo<\/span><\/p>\n<\/li>\n<li data-start=\"241\" data-end=\"300\">\n<p data-start=\"243\" data-end=\"300\"><strong data-start=\"243\" data-end=\"259\">Manufacturer<\/strong>: <span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Servier Pharmaceuticals<\/span><\/p>\n<\/li>\n<li data-start=\"301\" data-end=\"359\">\n<p data-start=\"303\" data-end=\"359\"><strong data-start=\"303\" data-end=\"318\">Formulation<\/strong>: <span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">250 mg oral tablets<\/span><\/p>\n<\/li>\n<li data-start=\"360\" data-end=\"505\">\n<p data-start=\"362\" data-end=\"505\"><strong data-start=\"362\" data-end=\"385\">Mechanism of Action<\/strong>: <span class=\"relative -mx-px my-[-0.2rem] rounded px-px py-[0.2rem] transition-colors duration-100 ease-in-out\">Ivosidenib is a targeted inhibitor of the isocitrate dehydrogenase-1 (IDH1) enzyme. By inhibiting mutated IDH1, it reduces the production of the oncometabolite 2-hydroxyglutarate (2-HG), thereby promoting the differentiation of malignant cells.<\/span><\/p>\n<\/li>\n<\/ul>\n","protected":false},"featured_media":4900,"comment_status":"open","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[32],"product_tag":[],"class_list":{"0":"post-4899","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-leukemia","7":"desktop-align-left","8":"tablet-align-left","9":"mobile-align-left","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-simple"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>TIBSOVO 250 MG TAB (IVOSIDENIB) - Curiance Biotech<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cbmeds.in\/?product=tibsovo-250-mg-tab-ivosidenib\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"TIBSOVO 250 MG TAB (IVOSIDENIB) - Curiance Biotech\" \/>\n<meta property=\"og:description\" content=\"\ud83e\uddec Overview of Ivosidenib (Tibsovo)    Generic Name: Ivosidenib    Brand Name: Tibsovo    Manufacturer: Servier Pharmaceuticals    Formulation: 250 mg oral tablets    Mechanism of Action: Ivosidenib is a targeted inhibitor of the isocitrate dehydrogenase-1 (IDH1) enzyme. 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