{"id":4901,"date":"2025-06-06T07:07:24","date_gmt":"2025-06-06T06:07:24","guid":{"rendered":"https:\/\/cbmeds.in\/?post_type=product&p=4901"},"modified":"2025-06-06T07:09:50","modified_gmt":"2025-06-06T06:09:50","slug":"koselugo-10mg-25mg-capsule-selumetinib","status":"publish","type":"product","link":"https:\/\/cbmeds.in\/?product=koselugo-10mg-25mg-capsule-selumetinib","title":{"rendered":"KOSELUGO 10MG \/25MG CAPSULE (SELUMETINIB)"},"content":{"rendered":"

\ud83e\uddec Introduction<\/strong><\/h3>\n

 <\/p>\n

Selumetinib is an oral MEK1\/2 inhibitor that targets the MAPK\/ERK pathway, which is often overactive in certain tumors,<\/span><\/p>\n

including those associated with NF1.<\/span> It is the first FDA-approved therapy specifically designed to reduce the size of plexiform <\/span><\/p>\n

neurofibromas in children.<\/span><\/p>\n

\n

\ud83d\udc8a Composition & Formulation<\/strong><\/h3>\n

 <\/p>\n

    \n
  • \n

    Generic Name<\/strong>: Selumetinib<\/span><\/p>\n<\/li>\n

  • \n

    Brand Name<\/strong>: Koselugo<\/span><\/p>\n<\/li>\n

  • \n

    Form<\/strong>: Oral capsules<\/span><\/p>\n<\/li>\n

  • \n

    Strengths Available<\/strong>: 10 mg and 25 mg<\/span><\/p>\n<\/li>\n

  • \n

    Manufacturer<\/strong>: AstraZeneca and MSD, Inc.<\/span><\/p>\n<\/li>\n<\/ul>\n

    \n

    \ud83d\udccb Approved Indication in India<\/strong><\/h3>\n

     <\/p>\n

    \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0Koselugo is approved for use in children aged 2 years and older with Neurofibromatosis Type 1 (NF1)<\/strong> who have <\/span><\/p>\n

    \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0symptomatic, inoperable plexiform neurofibromas (PN)<\/strong>.<\/span><\/p>\n

    \n

    \ud83d\udc8a Dosage & Administration<\/strong><\/h3>\n

     <\/p>\n

      \n
    • \n

      Recommended Dosage<\/strong>: 25 mg\/m\u00b2 taken orally twice daily.<\/span><\/p>\n<\/li>\n

    • \n

      Administration<\/strong>: Capsules should be swallowed whole on an empty stomach (no food or drink, except water, for 2 hours before and 1 hour after taking the dose).<\/span><\/p>\n<\/li>\n

    • \n

      Treatment Duration<\/strong>: Continue until disease progression or unacceptable toxicity occurs.<\/span><\/p>\n<\/li>\n<\/ul>\n

      \n

      \u26a0\ufe0f Side Effects<\/strong><\/h3>\n

       <\/p>\n

      \u00a0 \u00a0 \u00a0 \u00a0 Common Side Effects<\/strong>:<\/p>\n

        \n
      • \n

        Dry skin<\/span><\/p>\n<\/li>\n

      • \n

        Vomiting<\/span><\/p>\n<\/li>\n

      • \n

        Rash<\/p>\n<\/li>\n

      • \n

        Abdominal pain<\/span><\/p>\n<\/li>\n

      • \n

        Diarrhea<\/span><\/p>\n<\/li>\n

      • \n

        Nausea<\/span><\/p>\n<\/li>\n

      • \n

        Fatigue<\/span><\/p>\n<\/li>\n

      • \n

        Acneiform rash<\/span><\/p>\n<\/li>\n

      • \n

        Musculoskeletal pain<\/span><\/p>\n<\/li>\n

      • \n

        Fever<\/span><\/p>\n<\/li>\n

      • \n

        Stomatitis<\/span><\/p>\n<\/li>\n

      • \n

        Paronychia<\/span><\/p>\n<\/li>\n

      • \n

        Headache<\/span><\/p>\n<\/li>\n

      • \n

        Pruritus<\/span><\/p>\n<\/li>\n<\/ul>\n

        \u00a0 \u00a0 \u00a0 \u00a0Serious Side Effects<\/strong>:<\/p>\n

          \n
        • \n

          Decreased ejection fraction (heart function)<\/span><\/p>\n<\/li>\n

        • \n

          Ocular toxicity (e.g., blurred vision, retinal detachment)<\/span><\/p>\n<\/li>\n

        • \n

          Elevated creatine phosphokinase (CPK) levels, indicating potential muscle damage<\/span><\/p>\n<\/li>\n

        • \n

          Severe gastrointestinal toxicities (e.g., ileus, perforation)<\/span><\/p>\n<\/li>\n<\/ul>\n

          \n

          \u26a0\ufe0f Precautions & Warnings<\/strong><\/h3>\n

           <\/p>\n

            \n
          • \n

            Cardiac Monitoring<\/strong>: Assess left ventricular ejection fraction (LVEF) by echocardiogram before starting treatment, every 3 months during the first year, and every 6 months thereafter.<\/span><\/p>\n<\/li>\n

          • \n

            Ophthalmologic Evaluation<\/strong>: Conduct comprehensive eye exams at baseline and periodically during treatment.<\/span><\/p>\n<\/li>\n

          • \n

            Liver Function Tests<\/strong>: Monitor liver enzymes before and during treatment.<\/span><\/p>\n<\/li>\n

          • \n

            Pregnancy<\/strong>: Selumetinib may cause fetal harm. Advise females of reproductive potential to use effective contraception during treatment and for at least one week after the last dose.<\/span><\/p>\n<\/li>\n

          • \n

            Drug Interactions<\/strong>: Avoid concomitant use with strong CYP3A4 inhibitors or inducers, as they may affect selumetinib plasma concentrations.<\/span><\/p>\n<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

            Here are the key details for Koselugo<\/strong>:<\/p>\n

              \n
            • \n

              Brand Name<\/strong>: Koselugo<\/span><\/p>\n<\/li>\n

            • \n

              Generic Name (Salt)<\/strong>: Selumetinib<\/span><\/p>\n<\/li>\n

            • \n

              Manufacturer<\/strong>: AstraZeneca Pharmaceuticals LP<\/span><\/p>\n<\/li>\n

            • \n

              Formulation<\/strong>: Oral capsules<\/span><\/p>\n<\/li>\n

            • \n

              Available Strengths<\/strong>: 10 mg and 25 mg<\/span><\/p>\n<\/li>\n

            • \n

              Indication<\/strong>: Treatment of pediatric patients aged 2 years and older with neurofibromatosis type 1 (NF1) who have symptomatic, inoperable plexiform neurofibromas<\/span><\/p>\n<\/li>\n

            • \n

              Patent Status<\/strong>: Multiple patents protect Koselugo, with the latest expiring in March 2029. Consequently, generic versions are not expected before this date<\/span><\/p>\n<\/li>\n<\/ul>\n","protected":false},"featured_media":4902,"comment_status":"open","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[85],"product_tag":[],"class_list":{"0":"post-4901","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-neurofibromatosis","7":"desktop-align-left","8":"tablet-align-left","9":"mobile-align-left","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-simple"},"yoast_head":"\nKOSELUGO 10MG \/25MG CAPSULE (SELUMETINIB) - Curiance Biotech<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cbmeds.in\/?product=koselugo-10mg-25mg-capsule-selumetinib\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"KOSELUGO 10MG \/25MG CAPSULE (SELUMETINIB) - Curiance Biotech\" \/>\n<meta property=\"og:description\" content=\"Here are the key details for Koselugo: Brand Name: Koselugo Generic Name (Salt): Selumetinib Manufacturer: AstraZeneca Pharmaceuticals LP Formulation: Oral capsules Available Strengths: 10 mg and 25 mg Indication: Treatment of pediatric patients aged 2 years and older with neurofibromatosis type 1 (NF1) who have symptomatic, inoperable plexiform neurofibromas Patent Status: Multiple patents protect Koselugo, with the latest expiring in March 2029. 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