{"id":4904,"date":"2025-06-06T07:22:37","date_gmt":"2025-06-06T06:22:37","guid":{"rendered":"https:\/\/cbmeds.in\/?post_type=product&p=4904"},"modified":"2025-06-06T07:22:37","modified_gmt":"2025-06-06T06:22:37","slug":"rozlytrek-100mg-200mg-capsule-entrectinib","status":"publish","type":"product","link":"https:\/\/cbmeds.in\/?product=rozlytrek-100mg-200mg-capsule-entrectinib","title":{"rendered":"ROZLYTREK 100MG \/200MG CAPSULE (ENTRECTINIB)"},"content":{"rendered":"

Rozlytrek\u00ae (Entrectinib)<\/strong> is an oral targeted therapy approved for treating specific cancers driven by genetic mutations.<\/span> Here’s a comprehensive overview:<\/p>\n

\n

\ud83e\uddec Introduction<\/strong><\/h3>\n

 <\/p>\n

    \n
  • \n

    Generic Name<\/strong>: Entrectinib<\/span><\/p>\n<\/li>\n

  • \n

    Brand Name<\/strong>: Rozlytrek<\/span><\/p>\n<\/li>\n

  • \n

    Manufacturer<\/strong>: Genentech, Inc.\u00a0<\/span><\/p>\n<\/li>\n

  • \n

    Formulation<\/strong>: Hard capsules<\/span><\/p>\n<\/li>\n

  • \n

    Available Strengths<\/strong>: 100 mg and 200 mg<\/span><\/p>\n<\/li>\n<\/ul>\n

    \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Rozlytrek is a selective tyrosine kinase inhibitor designed to target tumors with specific gene fusions, notably ROS1<\/strong> and NTRK<\/strong>.<\/span><\/p>\n

    \n

    \ud83d\udccb Approved Indications<\/strong><\/h3>\n

     <\/p>\n

    \u00a0 \u00a0 \u00a0 \u00a0 Rozlytrek is indicated for:<\/span><\/p>\n

      \n
    1. \n

      ROS1-Positive Non-Small Cell Lung Cancer (NSCLC)<\/strong>:<\/p>\n

        \n
      • \n

        For adult patients with metastatic NSCLC whose tumors are ROS1-positive.<\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

      • \n

        NTRK Gene Fusion-Positive Solid Tumors<\/strong>:<\/p>\n

          \n
        • \n

          For adult and pediatric patients (12 years and older) with solid tumors that:<\/span><\/p>\n

            \n
          • \n

            Have a neurotrophic tyrosine receptor kinase (NTRK) gene fusion without a known acquired resistance mutation.<\/p>\n<\/li>\n

          • \n

            Are metastatic or where surgical resection is likely to result in severe morbidity.<\/p>\n<\/li>\n

          • \n

            Have progressed following treatment or have no satisfactory alternative therapy.<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n

            \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 These approvals are based on clinical trials demonstrating the efficacy of Rozlytrek in targeting these specific genetic alterations.<\/span><\/p>\n

            \n

            \ud83d\udc8a Dosage & Administration<\/strong><\/h3>\n

             <\/p>\n

              \n
            • \n

              Adults (ROS1-Positive NSCLC and NTRK Fusion-Positive Solid Tumors)<\/strong>:<\/p>\n

                \n
              • \n

                600 mg orally once daily, with or without food.<\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

              • \n

                Pediatric Patients (12 years and older) with NTRK Fusion-Positive Solid Tumors<\/strong>:<\/p>\n

                  \n
                • \n

                  Dosing is based on body surface area (BSA):<\/span><\/p>\n

                    \n
                  • \n

                    BSA \u22651.51 m\u00b2: 600 mg once daily.<\/p>\n<\/li>\n

                  • \n

                    BSA 1.11\u20131.50 m\u00b2: 500 mg once daily.<\/p>\n<\/li>\n

                  • \n

                    BSA 0.91\u20131.10 m\u00b2: 400 mg once daily.<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                    \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Continue treatment until disease progression or unacceptable toxicity.<\/span><\/p>\n

                    \n

                    \u26a0\ufe0f Side Effects<\/strong><\/h3>\n

                     <\/p>\n

                    \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Common Side Effects<\/strong>:<\/p>\n

                      \n
                    • \n

                      Fatigue<\/span><\/p>\n<\/li>\n

                    • \n

                      Constipation<\/span><\/p>\n<\/li>\n

                    • \n

                      Dysgeusia (altered taste)<\/span><\/p>\n<\/li>\n

                    • \n

                      Edema (swelling)<\/span><\/p>\n<\/li>\n

                    • \n

                      Dizziness<\/span><\/p>\n<\/li>\n

                    • \n

                      Diarrhea<\/span><\/p>\n<\/li>\n

                    • \n

                      Nausea<\/span><\/p>\n<\/li>\n

                    • \n

                      Dysesthesia (abnormal sensation)<\/span><\/p>\n<\/li>\n

                    • \n

                      Dyspnea (shortness of breath)<\/span><\/p>\n<\/li>\n

                    • \n

                      Anemia<\/span><\/p>\n<\/li>\n

                    • \n

                      Weight gain<\/span><\/p>\n<\/li>\n

                    • \n

                      Increased blood creatinine<\/span><\/p>\n<\/li>\n

                    • \n

                      Cognitive disorders (e.g., confusion, memory issues)<\/span><\/p>\n<\/li>\n

                    • \n

                      Vomiting<\/span><\/p>\n<\/li>\n

                    • \n

                      Cough<\/span><\/p>\n<\/li>\n

                    • \n

                      Fever<\/span><\/p>\n<\/li>\n<\/ul>\n

                      \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Side Effects<\/strong>:<\/p>\n

                        \n
                      • \n

                        Congestive heart failure (CHF)<\/span><\/p>\n<\/li>\n

                      • \n

                        Central nervous system effects (e.g., cognitive impairment, mood changes)<\/span><\/p>\n<\/li>\n

                      • \n

                        Vision disorders<\/span><\/p>\n<\/li>\n

                      • \n

                        Hepatotoxicity (liver injury)<\/span><\/p>\n<\/li>\n

                      • \n

                        Hyperuricemia (elevated uric acid levels)<\/span><\/p>\n<\/li>\n<\/ul>\n

                        \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0Patients should be monitored regularly for these adverse effects.<\/span><\/p>\n

                        \n

                        \u26a0\ufe0f Warnings & Precautions<\/strong><\/h3>\n

                         <\/p>\n

                          \n
                        • \n

                          Congestive Heart Failure (CHF)<\/strong>:<\/p>\n

                            \n
                          • \n

                            Assess left ventricular ejection fraction (LVEF) before initiating treatment. Monitor patients for signs and symptoms of CHF during treatment.<\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

                          • \n

                            Central Nervous System (CNS) Effects<\/strong>:<\/p>\n

                              \n
                            • \n

                              Monitor for cognitive changes, mood alterations, and other CNS effects. Adjust dosage or discontinue if severe symptoms occur.<\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

                            • \n

                              Hepatotoxicity<\/strong>:<\/p>\n

                                \n
                              • \n

                                Monitor liver function tests prior to and during treatment. Interrupt, reduce, or discontinue dosage based on severity.<\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

                              • \n

                                Hyperuricemia<\/strong>:<\/p>\n

                                  \n
                                • \n

                                  Monitor serum uric acid levels and manage with urate-lowering medications if necessary.<\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

                                • \n

                                  Embryo-Fetal Toxicity<\/strong>:<\/p>\n

                                    \n
                                  • \n

                                    Rozlytrek can cause fetal harm. Advise females of reproductive potential to use effective contraception during treatment and for at least 5 weeks after the final dose.<\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

                                  • \n

                                    Drug Interactions<\/strong>:<\/p>\n

                                      \n
                                    • \n

                                      Avoid concomitant use with strong CYP3A4 inhibitors or inducers. Monitor for adverse reactions when used with other medications.<\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

                                      \n

                                      \u2705 Conclusion<\/strong><\/h3>\n

                                       <\/p>\n

                                      \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Rozlytrek (Entrectinib) offers a targeted treatment option for patients with ROS1-positive NSCLC and NTRK fusion-positive solid tumors.<\/span> Its approval and availability in India\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 provide hope for improved management of these challenging conditions.<\/span> Patients should consult with healthcare professionals to determine suitability and to initiate appropriate\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 monitoring protocols during therapy.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

                                      Here’s a concise overview of Rozlytrek<\/strong>:<\/p>\n

                                        \n
                                      • \n

                                        Brand Name<\/strong>: Rozlytrek<\/span><\/p>\n<\/li>\n

                                      • \n

                                        Generic Name (Salt)<\/strong>: Entrectinib<\/span><\/p>\n<\/li>\n

                                      • \n

                                        Manufacturer<\/strong>: Genentech, Inc. (a member of the Roche Group)<\/span><\/p>\n<\/li>\n

                                      • \n

                                        Formulation<\/strong>: Oral capsules<\/span><\/p>\n<\/li>\n

                                      • \n

                                        Available Strengths<\/strong>: 100 mg and 200 mg<\/span><\/p>\n<\/li>\n

                                      • \n

                                        Indications<\/strong>:<\/p>\n

                                          \n
                                        • \n

                                          Treatment of adult patients with ROS1-positive metastatic non-small cell lung cancer (NSCLC)<\/span><\/p>\n<\/li>\n

                                        • \n

                                          Treatment of adult and pediatric patients 12 years of age and older with solid tumors that have a neurotrophic tyrosine receptor kinase (NTRK) gene fusion<\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

                                        • \n

                                          Availability in India<\/strong>: Accessible through authorized importers under named patient programs, such as Indian Pharma Network and GNH India<\/span><\/p>\n<\/li>\n<\/ul>\n","protected":false},"featured_media":4905,"comment_status":"open","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[31],"product_tag":[],"class_list":{"0":"post-4904","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-lung-cancer","7":"desktop-align-left","8":"tablet-align-left","9":"mobile-align-left","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-simple"},"yoast_head":"\nROZLYTREK 100MG \/200MG CAPSULE (ENTRECTINIB) - Curiance Biotech<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cbmeds.in\/?product=rozlytrek-100mg-200mg-capsule-entrectinib\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ROZLYTREK 100MG \/200MG CAPSULE (ENTRECTINIB) - Curiance Biotech\" \/>\n<meta property=\"og:description\" content=\"Here's a concise overview of Rozlytrek: Brand Name: Rozlytrek Generic Name (Salt): Entrectinib Manufacturer: Genentech, Inc. 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