{"id":4911,"date":"2025-06-06T08:14:51","date_gmt":"2025-06-06T07:14:51","guid":{"rendered":"https:\/\/cbmeds.in\/?post_type=product&p=4911"},"modified":"2025-06-06T08:15:42","modified_gmt":"2025-06-06T07:15:42","slug":"4911","status":"publish","type":"product","link":"https:\/\/cbmeds.in\/?product=4911","title":{"rendered":"WELIREG 40MG TAB ( BELZUTIFAN )"},"content":{"rendered":"

Welireg (Belzutifan)<\/strong> is an oral medication approved for the treatment of specific cancers associated with von Hippel-Lindau (VHL) disease and advanced renal cell carcinoma (RCC).<\/span><\/p>\n

\n

\ud83e\uddec Composition & Classification<\/strong><\/h3>\n

 <\/p>\n

    \n
  • \n

    Generic Name<\/strong>: Belzutifan<\/span><\/p>\n<\/li>\n

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    Brand Name<\/strong>: Welireg<\/span><\/p>\n<\/li>\n

  • \n

    Drug Class<\/strong>: Hypoxia-Inducible Factor-2 Alpha (HIF-2\u03b1) Inhibitor<\/span><\/p>\n<\/li>\n

  • \n

    Manufacturer<\/strong>: Merck & Co., Inc.<\/span><\/p>\n<\/li>\n<\/ul>\n

    \u00a0 \u00a0 \u00a0 \u00a0 Belzutifan functions by inhibiting HIF-2\u03b1, a transcription factor involved in tumor growth and survival under low oxygen conditions.<\/span><\/p>\n

    \n

    \ud83d\udccb Indications<\/strong><\/h3>\n

     <\/p>\n

    \u00a0 \u00a0 \u00a0 \u00a0Welireg is indicated for the treatment of adult patients with:<\/span><\/p>\n

      \n
    • \n

      von Hippel-Lindau (VHL) disease<\/strong> who require therapy for associated:<\/span><\/p>\n

        \n
      • \n

        Renal cell carcinoma (RCC)<\/span><\/p>\n<\/li>\n

      • \n

        Central nervous system (CNS) hemangioblastomas<\/span><\/p>\n<\/li>\n

      • \n

        Pancreatic neuroendocrine tumors (pNET)<\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

      • \n

        Advanced RCC<\/strong> following prior treatment with a PD-1 or PD-L1 inhibitor and a VEGF-TKI.<\/span><\/p>\n<\/li>\n<\/ul>\n

        \n

        \ud83d\udc8a Dosage & Administration<\/strong><\/h3>\n

         <\/p>\n

          \n
        • \n

          Recommended Dosage<\/strong>: 120 mg orally once daily (three 40 mg tablets)<\/span><\/p>\n<\/li>\n

        • \n

          Administration<\/strong>: Take with or without food at the same time each day. Swallow tablets whole; do not chew, crush, or split.<\/span><\/p>\n<\/li>\n

        • \n

          Missed Dose<\/strong>: If a dose is missed, take it as soon as possible on the same day. Resume the regular dosing schedule the next day. Do not take extra tablets to make up for the missed dose.<\/span><\/p>\n<\/li>\n<\/ul>\n

          \n

          \u26a0\ufe0f Warnings & Precautions<\/strong><\/h3>\n

           <\/p>\n

            \n
          • \n

            Embryo-Fetal Toxicity<\/strong>: Welireg can cause fetal harm. Verify pregnancy status prior to initiation. Advise females of reproductive potential to use effective non-hormonal contraception during treatment and for 1 week after the last dose.<\/span><\/p>\n<\/li>\n

          • \n

            Anemia<\/strong>: Welireg may cause severe anemia, potentially requiring blood transfusions. Monitor hemoglobin levels before and during treatment.<\/span><\/p>\n<\/li>\n

          • \n

            Hypoxia<\/strong>: Welireg can cause low oxygen levels, which may be severe and require discontinuation of therapy. Monitor oxygen levels before and during treatment.<\/span><\/p>\n<\/li>\n

          • \n

            Drug Interactions<\/strong>: Belzutifan may decrease the effectiveness of hormonal contraceptives by affecting CYP3A4 metabolism. Advise patients to use non-hormonal contraception.<\/span><\/p>\n<\/li>\n<\/ul>\n

            \n

            \u26a0\ufe0f Side Effects<\/strong><\/h3>\n

             <\/p>\n

            \u00a0 \u00a0 \u00a0 Common Side Effects<\/strong>:<\/p>\n

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            • \n

              Decreased hemoglobin (anemia)<\/span><\/p>\n<\/li>\n

            • \n

              Fatigue<\/span><\/p>\n<\/li>\n

            • \n

              Increased creatinine<\/span><\/p>\n<\/li>\n

            • \n

              Headache<\/span><\/p>\n<\/li>\n

            • \n

              Dizziness<\/span><\/p>\n<\/li>\n

            • \n

              Nausea<\/span><\/p>\n<\/li>\n

            • \n

              Increased glucose levels<\/span><\/p>\n<\/li>\n<\/ul>\n

              \u00a0 \u00a0 \u00a0 \u00a0Serious Side Effects<\/strong>:<\/p>\n

                \n
              • \n

                Hypoxia (low oxygen levels)<\/span><\/p>\n<\/li>\n

              • \n

                Anemia requiring transfusion<\/span><\/p>\n<\/li>\n

              • \n

                Pneumonia<\/span><\/p>\n<\/li>\n

              • \n

                Hemorrhage<\/span><\/p>\n<\/li>\n

              • \n

                Pleural effusion<\/span><\/p>\n<\/li>\n<\/ul>\n

                \n

                \u2705 Conclusion<\/strong><\/h3>\n

                 <\/p>\n

                Welireg (Belzutifan) offers a targeted treatment option for patients with VHL-associated tumors and advanced RCC.<\/span> Its mechanism of inhibiting HIF-2\u03b1 addresses the underlying pathophysiology of these conditions.<\/span> However, due to potential serious side effects such as anemia and hypoxia, careful monitoring and patient selection are essential.<\/span> Patients should discuss the risks and benefits of Welireg with their healthcare provider to determine its suitability for their treatment plan.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

                \ud83d\udccc Key Details<\/strong><\/h3>\n

                 <\/p>\n

                  \n
                • \n

                  Brand Name<\/strong>: Welireg<\/span><\/p>\n<\/li>\n

                • \n

                  Generic Name (Salt)<\/strong>: Belzutifan<\/span><\/p>\n<\/li>\n

                • \n

                  Manufacturer<\/strong>: Merck & Co., Inc.<\/span><\/p>\n<\/li>\n

                • \n

                  Formulation<\/strong>: Oral tablets<\/span><\/p>\n<\/li>\n

                • \n

                  Available Strength<\/strong>: 40 mg<\/span><\/p>\n<\/li>\n

                • \n

                  Indications<\/strong>:<\/p>\n

                    \n
                  • \n

                    Treatment of adults with von Hippel-Lindau (VHL) disease who require therapy for associated renal cell carcinoma (RCC), central nervous system (CNS) hemangioblastomas, or pancreatic neuroendocrine tumors (pNET) not requiring immediate surgery.<\/span><\/p>\n<\/li>\n

                  • \n

                    Treatment of adults with advanced clear cell RCC that progressed following treatment with a PD-1 or PD-L1 inhibitor and at least two VEGF-targeted therapies.<\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n","protected":false},"featured_media":4912,"comment_status":"open","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[86],"product_tag":[],"class_list":{"0":"post-4911","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-urothelial-carcinoma","7":"desktop-align-left","8":"tablet-align-left","9":"mobile-align-left","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-simple"},"yoast_head":"\nWELIREG 40MG TAB ( BELZUTIFAN ) - Curiance Biotech<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cbmeds.in\/?product=4911\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"WELIREG 40MG TAB ( BELZUTIFAN ) - Curiance Biotech\" \/>\n<meta property=\"og:description\" content=\"\ud83d\udccc Key Details   Brand Name: Welireg Generic Name (Salt): Belzutifan Manufacturer: Merck & Co., Inc. 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