{"id":4946,"date":"2025-06-10T08:14:35","date_gmt":"2025-06-10T07:14:35","guid":{"rendered":"https:\/\/cbmeds.in\/?post_type=product&p=4946"},"modified":"2025-06-10T08:14:35","modified_gmt":"2025-06-10T07:14:35","slug":"ayvakit-100mg-tab-avapritinib","status":"publish","type":"product","link":"https:\/\/cbmeds.in\/?product=ayvakit-100mg-tab-avapritinib","title":{"rendered":"AYVAKIT 100MG TAB (AVAPRITINIB)"},"content":{"rendered":"

\ud83e\uddec Indications<\/strong><\/h2>\n

 <\/p>\n

\n

Ayvakit is a prescription medicine used to treat adults with certain types of gastrointestinal stromal tumor (GIST) and systemic mastocytosis (SM). Ayvakit contains a drug called avapritinib, which belongs to the class of medicines called tyrosine kinase inhibitors. GIST is a cancer of the gastrointestinal tract most often caused by mutations in the platelet-derived growth factor receptor alpha (PDGFRA) protein, which is part of a family of proteins called receptor tyrosine kinases (RTKs). Ayvakit is used to treat:<\/p>\n

    \n
  1. \n

    Advanced Systemic Mastocytosis (AdvSM)<\/strong><\/p>\n<\/li>\n

  2. \n

    Aggressive Systemic Mastocytosis (ASM)<\/strong><\/p>\n<\/li>\n

  3. \n

    Systemic Mastocytosis with Associated Hematologic Neoplasm (SM-AHN)<\/strong><\/p>\n<\/li>\n

  4. \n

    Unresectable or metastatic gastrointestinal stromal tumor (GIST)<\/strong> with PDGFRA exon 18 mutations<\/strong>, including PDGFRA D842V<\/strong> mutation<\/p>\n<\/li>\n<\/ol>\n

    \u00a0 \u00a0 \u00a0 \u00a0 Approved by the US FDA<\/strong> for these rare diseases where other treatments are often ineffective.<\/p>\n

    \n

    \ud83d\udc8a Formulation & Strengths<\/strong><\/h2>\n

     <\/p>\n

      \n
    • \n

      Dosage Form<\/strong>: Oral tablets<\/p>\n<\/li>\n

    • \n

      Available Strengths<\/strong>: 25 mg, 50 mg, 100 mg, 200 mg, 300 mg<\/p>\n<\/li>\n<\/ul>\n

      \n

      \ud83e\uddea Typical Dosage<\/strong><\/h2>\n

       <\/p>\n

        \n
      • \n

        For PDGFRA exon 18 mutant GIST<\/strong>:
        \u2705 300 mg once daily<\/p>\n<\/li>\n

      • \n

        For advanced systemic mastocytosis<\/strong>:
        \u2705 Start with 200 mg once daily<\/strong>
        \u2705 May reduce based on toleran<\/p>\n<\/li>\n

      • \n

        Always taken <\/span>on an empty stomach<\/strong> \u2014 1 hour before or 2 hours after a meal.<\/span><\/p>\n<\/li>\n<\/ul>\n

        \n

        \u26a0\ufe0f Side Effects<\/strong><\/h2>\n

        \u00a0 \u00a0 \u00a0Common:<\/h3>\n

         <\/p>\n

          \n
        • \n

          Edema (swelling)<\/strong><\/p>\n<\/li>\n

        • \n

          Nausea, vomiting, diarrhea<\/strong><\/p>\n<\/li>\n

        • \n

          Fatigue, abdominal pain<\/strong><\/p>\n<\/li>\n

        • \n

          Cognitive effects<\/strong> (memory impairment, confusion)<\/p>\n<\/li>\n

        • \n

          Low blood counts<\/strong> (anemia, thrombocytopenia)<\/p>\n<\/li>\n<\/ul>\n

          \u00a0 \u00a0 \u00a0Serious:<\/h3>\n

           <\/p>\n

            \n
          • \n

            Intracranial bleeding (rare)<\/strong><\/p>\n<\/li>\n

          • \n

            Cognitive impairment<\/strong> (dose-related; reversible after stopping or reducing dose)<\/p>\n<\/li>\n<\/ul>\n

            \n

            \ud83d\udeab Warnings and Precautions<\/strong><\/h2>\n

             <\/p>\n

              \n
            • \n

              Avoid strong CYP3A inhibitors\/inducers<\/strong><\/p>\n<\/li>\n

            • \n

              Caution in patients with CNS conditions<\/strong><\/p>\n<\/li>\n

            • \n

              Baseline brain imaging<\/strong> may be recommended in patients with neurologic symptoms<\/p>\n<\/li>\n<\/ul>\n

              \n

              \u26a0\ufe0f Pregnancy & Lactation<\/strong><\/h2>\n

               <\/p>\n

                \n
              • \n

                May cause fetal harm<\/strong> \u2013 not recommended during pregnancy<\/p>\n<\/li>\n

              • \n

                Avoid breastfeeding while on treatment<\/p>\n<\/li>\n<\/ul>\n

                \n

                \u2705 Conclusion<\/strong><\/h2>\n

                 <\/p>\n

                \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Ayvakit (avapritinib)<\/strong> is a breakthrough therapy for patients with rare and aggressive forms of systemic mastocytosis<\/strong> or GIST with PDGFRA mutations<\/strong>.<\/p>\n

                \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0It selectively targets genetic abnormalities, offering new hope for patients who don\u2019t respond to conventional treatment. However, it requires<\/p>\n

                close monitoring<\/strong>, especially for brain-related side effects<\/strong> and blood counts.<\/p>\n","protected":false},"excerpt":{"rendered":"

                \ud83d\udccc Brand Name<\/strong>: Ayvakit<\/h2>\n

                \ud83d\udc8a Generic Name (Salt)<\/strong>: Avapritinib<\/strong><\/h2>\n

                \ud83c\udfed Manufacturer<\/strong>: Blueprint Medicines Corporation<\/h2>\n

                \ud83d\udca1 Drug Class<\/strong>: Tyrosine kinase inhibitor (TKI)<\/strong> \u2014 specifically targets PDGFRA<\/strong> and KIT<\/strong> mutations<\/h2>\n","protected":false},"featured_media":4947,"comment_status":"open","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[16],"product_tag":[],"class_list":{"0":"post-4946","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-uncategorised","7":"desktop-align-left","8":"tablet-align-left","9":"mobile-align-left","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-simple"},"yoast_head":"\nAYVAKIT 100MG TAB (AVAPRITINIB) - 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