{"id":4957,"date":"2025-06-11T09:02:51","date_gmt":"2025-06-11T08:02:51","guid":{"rendered":"https:\/\/cbmeds.in\/?post_type=product&p=4957"},"modified":"2025-06-11T09:03:15","modified_gmt":"2025-06-11T08:03:15","slug":"vizimpro-15mg-45mg-tab-dacomitinib","status":"publish","type":"product","link":"https:\/\/cbmeds.in\/?product=vizimpro-15mg-45mg-tab-dacomitinib","title":{"rendered":"VIZIMPRO 15MG\/ 45MG TAB (DACOMITINIB)"},"content":{"rendered":"

\ud83e\uddec Introduction<\/strong><\/h2>\n

 <\/p>\n

\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0Vizimpro <\/strong>\u00a0is a once-daily, oral tyrosine kinase inhibitor<\/strong> that irreversibly targets the epidermal growth factor receptor (EGFR). It\u2019s approved as first-line treatment<\/strong> for adults\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 with metastatic non-small cell lung cancer (NSCLC)<\/strong> harboring sensitizing EGFR exon\u202f19 deletions or exon\u202f21 L858R substitutions<\/strong>, confirmed via an FDA-approved test<\/p>\n

\n

\ud83d\udc8a Salt \/ Composition<\/strong><\/h2>\n

 <\/p>\n

    \n
  • \n

    Active Ingredient<\/strong>: Dacomitinib (an irreversible pan\u2011HER inhibitor)<\/span><\/p>\n<\/li>\n<\/ul>\n

    \n

    \ud83e\uddfe Dosage & Administration<\/strong><\/h2>\n

     <\/p>\n

      \n
    • \n

      Recommended Dose<\/strong>: 45\u202fmg orally once daily, with or without food<\/span> .<\/p>\n<\/li>\n

    • \n

      Dose Reductions<\/strong>:<\/p>\n

        \n
      • \n

        1st level: 30\u202fmg daily<\/span><\/p>\n<\/li>\n

      • \n

        2nd level: 15\u202fmg daily<\/span><\/p>\n<\/li>\n<\/ul>\n<\/li>\n

      • \n

        Adjustments<\/strong> are made based on side effects such as diarrhea or rash.<\/span><\/p>\n<\/li>\n<\/ul>\n

        \n

        \u26a0\ufe0f Side Effects<\/strong><\/h2>\n

         <\/p>\n

        \u00a0 \u00a0 \u00a0Very Common (>20%)<\/strong><\/h3>\n
          \n
        • \n

          Diarrhea (87%)<\/p>\n<\/li>\n

        • \n

          Rash (69%)<\/p>\n<\/li>\n

        • \n

          Paronychia (64%)<\/p>\n<\/li>\n

        • \n

          Stomatitis (45%)<\/p>\n<\/li>\n

        • \n

          Dry skin (30%)<\/span><\/p>\n<\/li>\n

        • \n

          Decreased appetite (31%)<\/span><\/p>\n<\/li>\n

        • \n

          Weight loss (26%)<\/span><\/p>\n<\/li>\n

        • \n

          Alopecia (23%)<\/p>\n<\/li>\n

        • \n

          Cough (21%)<\/p>\n<\/li>\n

        • \n

          Pruritus (21%)<\/p>\n<\/li>\n

        • \n

          Plus: nail disorders, mouth sores, eye irritation, hair changes<\/span><\/p>\n<\/li>\n<\/ul>\n

          \u00a0 \u00a0 \u00a0Serious Adverse Reactions<\/strong><\/h3>\n

           <\/p>\n

            \n
          • \n

            Diarrhea<\/strong> grade\u202f3\/4 (11%)\u2014can be severe\/dehydrating<\/span><\/p>\n<\/li>\n

          • \n

            Interstitial lung disease (ILD)\/pneumonitis<\/strong>: ~0.5% cases, fatal in ~0.3%<\/span><\/p>\n<\/li>\n

          • \n

            Dermatologic<\/strong> grade\u202f3\/4 rash or exfoliation: 21%; skin reactions often require treatment interruption or dose reduction<\/span><\/p>\n<\/li>\n

          • \n

            Other<\/strong>: mouth sores, infections under nails, dehydration<\/span><\/p>\n<\/li>\n<\/ul>\n

            \n

            \ud83e\uddea Warnings & Precautions<\/strong><\/h2>\n

             <\/p>\n

              \n
            • \n

              Interstitial Lung Disease<\/strong>: Monitor for respiratory symptoms; permanently discontinue if ILD confirmed<\/span><\/p>\n<\/li>\n

            • \n

              Diarrhea<\/strong>: Promptly treat with anti-diarrheals; pause therapy at grade\u202f\u2265\u202f2 until resolution<\/span> .<\/p>\n<\/li>\n

            • \n

              Skin Reactions<\/strong>: Use moisturizers, sun protection, topical\/oral antibiotics; interrupt treatment at grade\u202f2+<\/span>.<\/p>\n<\/li>\n

            • \n

              Pregnancy Risk<\/strong>: Potential fetal harm\u2014effective contraception during and for at least 17 days post-treatment<\/span> .<\/p>\n<\/li>\n

            • \n

              Monitoring<\/strong>: Regular assessment of hydration, skin, mucosa, pulmonary status.<\/p>\n<\/li>\n<\/ul>\n

              \n

              \u2705 Conclusion<\/strong><\/h2>\n

               <\/p>\n

              Vizimpro offers an effective first-line EGFR-targeted therapy<\/strong> for NSCLC with sensitizing mutations, delivering improved progression-free survival (e.g., ARCHER 1050 data). However, it is associated with high rates of dermatologic toxicity, diarrhea, and rare but serious pulmonary risks<\/strong>, necessitating vigilant side effect management and dose adjustments. Proper patient education, routine monitoring, and proactive supportive care are essential to maximize benefit while minimizing harm.<\/p>\n","protected":false},"excerpt":{"rendered":"

              Brand Name<\/strong>: Vizimpro<\/strong>
              Salt\/Generic Name<\/strong>: Dacomitinib<\/strong> (dacomitinib monohydrate)
              Manufacturer<\/strong>: Pfizer Inc.<\/strong>
              Formulation<\/strong>: Film-coated oral tablets<\/strong>
              Available Strengths<\/strong>: 15\u202fmg, 30\u202fmg, and 45\u202fmg<\/strong>
              Indication<\/strong>: First-line treatment for metastatic EGFR-mutant (exon\u202f19 del or L858R) non-small cell lung cancer (NSCLC)<\/strong><\/p>\n","protected":false},"featured_media":4959,"comment_status":"open","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[31],"product_tag":[],"class_list":{"0":"post-4957","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-lung-cancer","7":"desktop-align-left","8":"tablet-align-left","9":"mobile-align-left","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-simple"},"yoast_head":"\nVIZIMPRO 15MG\/ 45MG TAB (DACOMITINIB) - 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