EXKIVITY 40 MG CAPSULE ( MOBOCERTINIB )

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Brand Name: EXKIVITY

Generic Name: Mobocertinib

Strength: 40 mg capsules

Form: Oral capsule

Manufacturer: Takeda Pharmaceuticals

Product Meta

Category

Country of Origin

India

MEDICINE APPROVED BY

DISEASE INDICATIONS

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Payments can be made by credit card or bank transfer. Payments are fully encrypted and secure. When paying by credit card, you can pay online once you have received your order confirmation. Please be aware that a 2.8% fee applies when paying by credit card.
 
Payments can be made by credit card or bank transfer. Payments are fully encrypted and secure. When paying by credit card, you can pay online once you have received your order confirmation. Please be aware that a 2.8% fee applies when paying by credit card.
 
Payments can be made by credit card or bank transfer. Payments are fully encrypted and secure. When paying by credit card, you can pay online once you have received your order confirmation. Please be aware that a 2.8% fee applies when paying by credit card.
 
Payments can be made by credit card or bank transfer. Payments are fully encrypted and secure. When paying by credit card, you can pay online once you have received your order confirmation. Please be aware that a 2.8% fee applies when paying by credit card.
 
Payments can be made by credit card or bank transfer. Payments are fully encrypted and secure. When paying by credit card, you can pay online once you have received your order confirmation. Please be aware that a 2.8% fee applies when paying by credit card.
 

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Dr. Akshi Sudan

Patient Support Team Lead

Dr. Akshi Sudan

Patient Support Team Lead

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What is Exkivity?

Exkivity (mobocertinib) is a tyrosine kinase inhibitor (TKI) used to treat non-small cell lung cancer (NSCLC) that has a specific EGFR gene mutation. Exkivity reduces the growth of non-small cell lung cancer by binding to and inhibiting EGFR exon 20 insertion mutations.

Exkivity capsules can be used by adults with non-small cell lung cancer that has spread to other parts of the body (metastatic) and cannot be removed with surgery, whose disease has worsened while on or after chemotherapy with platinum, and has cancer has epidermal growth factor receptor (EGFR) exon 20 insertion mutation.

How does Exkivity work?

Epidermal growth factor receptor (EGFR) is a protein that helps cells to grow and divide.  When EGFR has an exon 20 insertion mutation, it drives cells to grow and divide abnormally, causing an EGFR-positive cancer.  Exkivity works by binding to and blocking EGFR exon 20 insertion mutations, which helps to slow the growth of cancer cells.

What is EXKIVITY Used For?

EXKIVITY is used for the treatment of:

Non-Small Cell Lung Cancer (NSCLC)
✅ In adult patients with EGFR exon 20 insertion mutations
✅ Specifically for metastatic NSCLC that has progressed on or after platinum-based chemotherapy


Mechanism of Action:

Mobocertinib is a tyrosine kinase inhibitor (TKI) designed to specifically target EGFR exon 20 insertion mutations, inhibiting abnormal cell signaling and growth.


Administration:

  • Oral, once daily (usually 160 mg — 4 capsules of 40 mg each)

  • Taken on an empty stomach (at least 1 hour before or 2 hours after eating)


Common Side Effects:

  • Diarrhea (very common)

  • Rash

  • Nausea

  • Vomiting

  • Fatigue

  • Stomatitis

  • Loss of appetite

  • QT prolongation (requires ECG monitoring)


Warnings:

  • Monitor heart function (ECG, electrolytes)

  • Liver enzymes and pulmonary symptoms should also be regularly checked

  • May cause severe diarrhea — supportive care may be required


Approval Status:

  • Received accelerated approval from the U.S. FDA for this rare mutation type

This content has been reviewed by a Medical Doctor.
 

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This content has been reviewed by a Medical Doctor.