Product Meta
Country of Origin
India
MEDICINE APPROVED BY
- Indian Medical Agency (IMA)
- Food and Drug Administration (FDA)
- Health Asia
DISEASE INDICATIONS
- European Medical Agency (EMA)
- Food and Drug Administration (FDA)
- Health India
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Payments can be made by credit card or bank transfer. Payments are fully encrypted and secure. When paying by credit card, you can pay online once you have received your order confirmation. Please be aware that a 2.8% fee applies when paying by credit card.
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Payments can be made by credit card or bank transfer. Payments are fully encrypted and secure. When paying by credit card, you can pay online once you have received your order confirmation. Please be aware that a 2.8% fee applies when paying by credit card.
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Payments can be made by credit card or bank transfer. Payments are fully encrypted and secure. When paying by credit card, you can pay online once you have received your order confirmation. Please be aware that a 2.8% fee applies when paying by credit card.
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Payments can be made by credit card or bank transfer. Payments are fully encrypted and secure. When paying by credit card, you can pay online once you have received your order confirmation. Please be aware that a 2.8% fee applies when paying by credit card.
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Payments can be made by credit card or bank transfer. Payments are fully encrypted and secure. When paying by credit card, you can pay online once you have received your order confirmation. Please be aware that a 2.8% fee applies when paying by credit card.
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Dr. Akshi Sudan
Patient Support Team Lead
Dr. Akshi Sudan
Patient Support Team Lead
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What is Gavreto?
Gavreto (pralsetinib) is an oral prescription medicine that may be used to treat the following cancers caused by abnormal RET (rearranged during transfection) genes that have spread (metastasized):
- non-small cell lung cancer (NSCLC) in adults
- advanced thyroid cancer or thyroid cancer in adults and children 12 years of age and older who require a medicine by mouth or injection (systemic therapy) and who have received radioactive iodine and it did not work or is no longer working.
âś… Indications:
GAVRETO 100 mg is used to treat cancers with RET gene alterations, including:
1. RET Fusion–Positive Non-Small Cell Lung Cancer (NSCLC)
Advanced/metastatic
First-line or second-line treatment
2. RET-Mutant Medullary Thyroid Cancer (MTC)
Locally advanced or metastatic
For patients who require systemic therapy
3. RET Fusion–Positive Thyroid Cancer
Radioactive iodine–refractory (if eligible)
âś… RET mutation or fusion must be confirmed with a validated molecular test (e.g. NGS, FISH).
đź’Š Dosage (for Adults):
400 mg once daily (4 x 100 mg capsules)
Take on an empty stomach (at least 2 hours before or after food)
Continue until disease progression or toxicity
⚙️ Mechanism of Action:
GAVRETO is a selective RET kinase inhibitor
It blocks the RET signaling pathway, which is abnormally activated in certain cancers due to RET mutations or gene fusions, helping to shrink or slow tumor growth.
⚠️ Common Side Effects:
| Common | Monitor for |
|---|---|
| Constipation, fatigue | Liver enzymes (ALT, AST) |
| Anemia, low WBC count | Pulmonary issues (ILD/pneumonitis) |
| Hypertension | QT prolongation (ECG) |
| Edema, dry mouth, rash | Kidney function (creatinine levels) |
| Increased liver enzymes | Thyroid function |
🧪 Monitoring Guidelines:
Liver function tests (ALT/AST) regularly
Complete blood count (CBC)
Electrocardiogram (ECG) for QT interval
Pulmonary symptoms (e.g., cough, breathlessness)
This content has been reviewed by a Medical Doctor.
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This content has been reviewed by a Medical Doctor.
