Product Meta
Country of Origin
India
MEDICINE APPROVED BY
- Indian Medical Agency (IMA)
- Food and Drug Administration (FDA)
- Health Asia
DISEASE INDICATIONS
- European Medical Agency (EMA)
- Food and Drug Administration (FDA)
- Health India
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FREQUENTLY ASKED QUESTIONS
Payments can be made by credit card or bank transfer. Payments are fully encrypted and secure. When paying by credit card, you can pay online once you have received your order confirmation. Please be aware that a 2.8% fee applies when paying by credit card.
Payments can be made by credit card or bank transfer. Payments are fully encrypted and secure. When paying by credit card, you can pay online once you have received your order confirmation. Please be aware that a 2.8% fee applies when paying by credit card.
Payments can be made by credit card or bank transfer. Payments are fully encrypted and secure. When paying by credit card, you can pay online once you have received your order confirmation. Please be aware that a 2.8% fee applies when paying by credit card.
Payments can be made by credit card or bank transfer. Payments are fully encrypted and secure. When paying by credit card, you can pay online once you have received your order confirmation. Please be aware that a 2.8% fee applies when paying by credit card.
Payments can be made by credit card or bank transfer. Payments are fully encrypted and secure. When paying by credit card, you can pay online once you have received your order confirmation. Please be aware that a 2.8% fee applies when paying by credit card.
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- We have delivered medicines to more than 88 countries. Check if we have sent medicines to yours.
Our Patient Support Team will personally assist you along the way
Dr. Akshi Sudan
Patient Support Team Lead
Dr. Akshi Sudan
Patient Support Team Lead
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🧬 Indications
Ayvakit is a prescription medicine used to treat adults with certain types of gastrointestinal stromal tumor (GIST) and systemic mastocytosis (SM). Ayvakit contains a drug called avapritinib, which belongs to the class of medicines called tyrosine kinase inhibitors. GIST is a cancer of the gastrointestinal tract most often caused by mutations in the platelet-derived growth factor receptor alpha (PDGFRA) protein, which is part of a family of proteins called receptor tyrosine kinases (RTKs). Ayvakit is used to treat:
Advanced Systemic Mastocytosis (AdvSM)
Aggressive Systemic Mastocytosis (ASM)
Systemic Mastocytosis with Associated Hematologic Neoplasm (SM-AHN)
Unresectable or metastatic gastrointestinal stromal tumor (GIST) with PDGFRA exon 18 mutations, including PDGFRA D842V mutation
Approved by the US FDA for these rare diseases where other treatments are often ineffective.
💊 Formulation & Strengths
Dosage Form: Oral tablets
Available Strengths: 25 mg, 50 mg, 100 mg, 200 mg, 300 mg
🧪 Typical Dosage
For PDGFRA exon 18 mutant GIST:
✅ 300 mg once dailyFor advanced systemic mastocytosis:
✅ Start with 200 mg once daily
✅ May reduce based on toleranAlways taken on an empty stomach — 1 hour before or 2 hours after a meal.
⚠️ Side Effects
Common:
Edema (swelling)
Nausea, vomiting, diarrhea
Fatigue, abdominal pain
Cognitive effects (memory impairment, confusion)
Low blood counts (anemia, thrombocytopenia)
Serious:
Intracranial bleeding (rare)
Cognitive impairment (dose-related; reversible after stopping or reducing dose)
🚫 Warnings and Precautions
Avoid strong CYP3A inhibitors/inducers
Caution in patients with CNS conditions
Baseline brain imaging may be recommended in patients with neurologic symptoms
⚠️ Pregnancy & Lactation
May cause fetal harm – not recommended during pregnancy
Avoid breastfeeding while on treatment
✅ Conclusion
Ayvakit (avapritinib) is a breakthrough therapy for patients with rare and aggressive forms of systemic mastocytosis or GIST with PDGFRA mutations.
It selectively targets genetic abnormalities, offering new hope for patients who don’t respond to conventional treatment. However, it requires
close monitoring, especially for brain-related side effects and blood counts.
This content has been reviewed by a Medical Doctor.
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This content has been reviewed by a Medical Doctor.
