VEOZAH 45 MG TAB (FEZOLINETANT)

🧬 Indication

       Veozah is used for:

• Treatment of moderate to severe vasomotor symptoms (VMS) associated with menopause .

        It’s the first non-hormonal treatment specifically approved for menopausal hot flashes.
       ✅ FDA Approved: May 2023 (USA)

💊 Formulation & Dosage

• Dosage Form: Oral tablets

• Strength: 45 mg

• Recommended Dose:

  • One 45 mg tablet once daily, at the same time each day

  • Can be taken with or without food

⚠️ Important Side Effects

     Common:

• Abdominal pain

• Diarrhea

• Insomnia

• Back pain

• Hot flush (initial increase before relief)

     Liver-related:

• Elevated liver enzymes (ALT/AST)

• Rare risk of serious liver injury

🚫 Warnings & Precautions

• Contraindicated in patients with:

  • Severe liver impairment

  • Known hypersensitivity to fezolinetant

• Use with caution in patients taking medications metabolized by CYP1A2

• Not recommended in pregnancy and breastfeeding

🔁 Drug Interactions

• Avoid use with strong CYP1A2 inhibitors (e.g., fluvoxamine)

• Careful monitoring with other liver-metabolized drugs

✅ Conclusion

         Veozah (fezolinetant) is a groundbreaking, non-hormonal oral option for managing menopausal hot flashes, particularly helpful for women who cannot or prefer not to             use estrogen therapy. It targets the hypothalamic thermoregulation pathway by blocking NK3 receptors, helping regulate body temperature.

         It’s a daily pill, generally well-tolerated, but requires liver monitoring.