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FILSPARI 200MG /400MG TAB (SPARSENTAN)

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Important Guide

Sparsentan, marketed under the brand name FILSPARI®, is an oral medication developed by Travere Therapeutics. It is approved for treating adults with primary immunoglobulin A nephropathy (IgAN) who are at risk of disease progression.

🔹 Key Details

Manufacturer: Travere Therapeutics
Brand Name: FILSPARI®
Dosage Forms: Film-coated tablets in 200 mg and 400 mg strengths
Mechanism of Action: Dual antagonist of endothelin type A (ETA) and angiotensin II type 1 (AT1) receptors, aiming to reduce proteinuria and slow kidney function decline
Indications: Approved for the treatment of primary IgA nephropathy (IgAN) in adults at risk of disease progression
Dosing:
- Start with 200 mg orally once daily for 14 days
- Increase to 400 mg once daily, as tolerated

Product Meta

Categories immunoglobulin A (IgA) nephropathy, Immunosuppressants

Country of Origin

India

MEDICINE APPROVED BY

DISEASE INDICATIONS

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Filspari (sparsentan)

Overview: Filspari (sparsentan) is used to treat an autoimmune condition that affects the kidneys called immunoglobulin A (IgA) nephropathy. It works by blocking receptors that cause inflammation and damage to the kidneys, which helps slow down the disease. Common side effects include high potassium levels, low blood pressure, fluid retention, and dizziness. Filspari can also cause liver damage, which can be serious.

What is Filspari used for?

Filspari (sparsentan) is commonly used to treat certain people with an autoimmune condition that affects the kidneys called immunoglobulin A (IgA) nephropathy.

Filspari may also be used for other conditions as determined by your healthcare provider.

What Are Side Effects of Filspari?

Filspari may cause serious side effects including:

hives,
difficulty breathing,
swelling of your face, lips, tongue, or throat,
nausea,
vomiting,
stomach pain (upper right side),
tiredness,
loss of appetite,
yellowing of the skin or eyes (jaundice),
dark urine,
fever,
itching,
serious birth defects,
low blood pressure,
dizziness,
lightheadedness,
fainting,
muscle cramps,
dry skin,
shortness of breath,
trouble sleeping,
frequent urination,
little or no urination,
abnormal blood test results (increased potassium),
unusual weight gain, and
swelling of your ankles or legs

Get medical help right away, if you have any of the symptoms listed above.

Side effects of Filspari include:

swelling of extremities,
low blood pressure (hypotension),
dizziness,
high potassium levels (hyperkalemia), and
low iron levels (anemia).

💊 Dosage Forms and Strengths

200 mg Tablets: White to off-white, oval-shaped, film-coated tablets debossed with “105” on one side.
400 mg Tablets: White to off-white, oval-shaped, film-coated tablets debossed with “021” on one side.

💊 Recommended Dosage

Initial Dose: 200 mg orally once daily for the first 14 days.
Maintenance Dose: After 14 days, increase to 400 mg once daily, as tolerated.
Administration: Swallow tablets whole with water before the morning or evening meal. Maintain the same dosing pattern in relation to meals.

⚠️ Important Safety Information

Contraindications: Pregnancy, coadministration with angiotensin receptor blockers (ARBs), endothelin receptor antagonists (ERAs), or aliskiren.
Warnings and Precautions:
- Hypotension
- Acute Kidney Injury
- Hyperkalemia
- Fluid Retention

This content has been reviewed by a Medical Doctor.

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