OJJAARA 100/150/200 MG TAB (MOMELOTINIB)

What is Ojjaara?

Ojjaara (momelotinib) may be used to treat adults with certain types of myelofibrosis (MF) who have anemia.

Myelofibrosis is a rare blood cancer where the bone marrow becomes scarred, preventing it from producing enough healthy blood cells. Over time, abnormal blood cells build up and replace normal ones. The exact cause is unknown, but it’s linked to a problem with a specific cell signaling pathway, called the JAK-STAT pathway. Treatment usually involves managing symptoms such as anemia and an enlarged spleen.

Ojjaara’s mechanism of action involves targeting and blocking specific enzymes called JAK1, JAK2, and a mutated form of JAK2. These enzymes are involved in regulating blood cell production and inflammation. Mutations in these enzymes have been associated with certain blood cancers like several leukemias, lymphomas, and myeloproliferative diseases. Ojjaara is not chemotherapy, it is a targeted treatment.

🔬 Composition & Mechanism

• Active Ingredient: Momelotinib

• Drug Class: Janus kinase (JAK) inhibitor

• Mechanism of Action: Inhibits JAK1, JAK2, and activin A receptor type I (ACVR1), leading to decreased hepcidin production, improved iron availability, and enhanced red blood cell production.

💊 Dosage & Administration

• Recommended Dose: 200 mg orally once daily

• Administration: Can be taken with or without food; tablets should be swallowed whole without cutting, crushing, or chewing.

• Missed Dose: If a dose is missed, take the next scheduled dose the following day.

What are the most common side effects of Ojjaara?

The most common side effects of Ojjaara are listed below. Tell your healthcare provider if you have any of these side effects that bother you.

• Low platelet levels
• Bleeding
• Bacterial infection
• Tiredness
• Dizziness
• Diarrhea
• Nausea

What are the serious side effects of Ojjaara?

While less common, the most serious side effects of Ojjaara are described below, along with what to do if they happen.

            Severe Allergic Reactions. Ojjaara may cause allergic reactions, which can be serious. Stop taking Ojjaara and get help right away if you have any of the

following symptoms of a serious allergic reaction.

• Breathing problems or wheezing
• Racing heart
• Fever or general ill feeling
• Swollen lymph nodes
• Swelling of the face, lips, mouth, tongue, or throat
• Trouble swallowing or throat tightness
• Itching, skin rash, or pale red bumps on the skin called hives
• Nausea or vomiting
• Dizziness, feeling lightheaded, or fainting
• Stomach cramps
• Joint pain

⚠️ Warnings & Precautions

• Hematologic Toxicity: Risk of thrombocytopenia and neutropenia; regular monitoring of blood counts is recommended.

• Infections: Increased susceptibility to infections, including bacterial infections; patients should be monitored for signs of infection.

• Liver Dysfunction: Potential for elevated liver enzymes; liver function tests should be performed periodically.

• Cardiovascular Events: Risk of major cardiovascular events such as heart attack and stroke, especially in patients with existing risk factors.

• Pregnancy & Lactation: Not recommended during pregnancy or breastfeeding due to potential harm to the fetus or infant.