AXPERO 1MG/ 5MG TAB (AXITINIB)

Axpero 5 mg Tablet is an anti-cancer medicine used in the treatment of renal cell carcinoma. Renal cell carcinoma, also known as kidney cancer, is a disease in which the cancer or malignant cells grow uncontrollably in the kidney and form a tumour.

Axpero 5 mg Tablet contains Axitinib as an active ingredient, which belongs to the class of medicines known as kinase inhibitors. It works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells.

📌 Brand & Composition

• Brand Name: Axpero

• Generic Name (Salt): Axitinib

• Manufacturer: Intas Pharmaceuticals Ltd, India

• Formulation: Oral tablets

• Available Strengths: 1 mg and 5 mg

🏥 Indication

             Indicated for the treatment of advanced or metastatic renal cell carcinoma (kidney cancer) in adults

💊 Dosage & Administration

• Usual Dose: 5 mg orally twice daily, approximately 12 hours apart (taken with or without food).

• Administration: Swallow whole; do not break or crush.

• Missed Dose: If within 6–12 hours of the next dose, skip and resume the regular schedule

⚠️ Safety & Precautions

✔️ Common Side Effects

• Hypertension

• Diarrhea, nausea, vomiting, constipation

• Fatigue, decreased appetite, weight loss

• Hypothyroidism

✔️ Additional Side Effects

• Dry skin, dizziness, muscle pain, anemia

• Headache, nosebleeds, voice change, ringing in ears

• Increased liver enzymes, lipase/amylase, dehydration, pulmonary embolism and bleeding

✔️ Serious Risks

• Thrombotic and hemorrhagic events, such as pulmonary embolism

• Hypertension: monitor regularly

• Hypothyroidism, RPLS, GI perforation

⚠️ Warnings

• Avoid in pregnancy and breastfeeding—definite fetal harm; use effective contraception .

• May impair driving/drinking due to dizziness or vision changes .

• Liver caution: dose adjustment may be needed in hepatic impairment .

• Kidney disease: safe at prescribed doses; monitor function .

🔗 Drug Interactions

• Avoid strong CYP3A4 inhibitors/inducers (clarithromycin, ketoconazole, phenytoin, rifampin, etc.)

• Anticoagulants (warfarin, phenindione) may increase bleeding risk; monitor closely

• Be cautious with bevacizumab and other agents that increase bleeding potential

💰 Pricing & Availability in India

• Axpero 1 mg (14 tablets): approx ₹495–544 

• Axpero 5 mg (14 tablets): approx ₹1,645–2,200

✅ Conclusion

        Axpero (axitinib) is an effective twice-daily treatment for advanced kidney cancer, with a well-known efficacy and side-effect profile reminiscent of the

        original brand Inlyta. It requires:

• Ongoing blood pressure and thyroid monitoring

• Vigilance for serious bleeding or embolic events

• Caution with drug interactions

• Use of pregnancy precautions