KYZIFIC 40 MG ( ASCIMINIB )

Kyzific 40mg Tablet is a prescription medication containing Asciminib, developed by Novartis India Ltd. It is primarily used to treat adults with Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in the chronic phase, especially for patients who have previously been treated with two or more tyrosine kinase inhibitors (TKIs) and did not respond adequately.

🧬 How Kyzific Works

Asciminib, the active ingredient in Kyzific, is a novel tyrosine kinase inhibitor that uniquely targets the BCR-ABL1 protein by binding to the myristoyl pocket—a mechanism distinct from traditional TKIs. This targeted approach helps inhibit the proliferation of leukemic cells, including those with mutations that confer resistance to other TKIs.

💊 Dosage & Administration

• Dosage: As prescribed by your oncologist, typically taken orally.

• Administration: Take Kyzific on an empty stomach—at least 2 hours before or 1 hour after eating—to ensure proper absorption. Swallow the tablet whole with water; do not crush or chew.

⚠️ Side Effects & Precautions

Common Side Effects:

• Nausea

• Diarrhea

• Headache

• Fatigue

• Muscle pain

Serious Side Effects:

• Low blood cell counts (anemia, neutropenia, thrombocytopenia)

• Pancreatitis

• Hypertension

• Elevated liver enzymes

Precautions:

• Avoid grapefruit and grapefruit juice during treatment, as they can interfere with the medication’s effectiveness.

• Inform your doctor about all other medications, supplements, or herbal products you are taking, as Kyzific can interact with other substances.

• Use effective contraception during treatment and avoid pregnancy, as Kyzific can harm the developing fetus.

• Regular monitoring of blood counts, liver function, and blood pressure is essential during treatment.

💰 Pricing & Availability in India

Kyzific 40mg Tablet is available in India through various pharmacies