MULPLETA (LUSUTROMBOPAG)

What is Mulpleta?

Mulpleta is a man-made form of a protein that increases production of platelets (blood-clotting cells) in your body. Lusutrombopag can lower the risk of bleeding by increasing platelets in your blood. Mulpleta is used to treat thrombocytopenia (a lack of platelets in the blood) in adults with chronic liver disease who are scheduled to undergo a medical procedure.

📌 Brand & Composition

• Brand: Mulpleta

• Generic Name (Salt): Lusutrombopag

• Drug Class: Thrombopoietin Receptor Agonist (TPO‑RA)

🏥 Indication

• For adult patients with chronic liver disease-associated thrombocytopenia (platelets < 50×10⁹/L) who are scheduled to undergo an invasive procedure

💊 Dosage & Administration

• Dose: 3 mg orally once daily for 7 days, starting 8–14 days before the procedure

• Timing: Procedure should occur 2–8 days after the last dose

• Food: Can be taken with or without meals .

• Missed Dose: Take as soon as remembered on the same day; do not double up.

⚠️ Warnings & Precautions

• Thromboembolic Risk: Higher risk if platelets become too high or in patients with clotting disorders; monitor platelet counts closely

• Contraindications: Hypersensitivity to lusutrombopag.

• Pregnancy/Lactation: Not recommended; breastfeeding should be avoided for at least 28 days post-treatment

⚠️ Side Effects

• Common: Headache (~5%) .

• Serious: Blood clots (e.g., stroke, portal vein thrombosis) if platelet counts rise too high .

• Overdose: May lead to excessive platelet elevation and thrombosis—no specific antidote; manage according to standard care

⚕️ Clinical Evidence

• Efficacy: In the L-PLUS 1/2 trials, ~76–78% of Mulpleta-treated patients did not require platelet transfusion, compared to 6–13% with placebo

• Demonstrated similar efficacy across age, sex, and race .

📊 Pharmacology

• Mechanism: Stimulates TPO receptors to promote platelet production.

• Half-Life: ~27 hours; steady-state by Day 5

• Metabolism: Primarily CYP4, and highly protein-bound (>99.9%)

    🇮🇳 Availability in India

• Imported via Named Patient Supply, facilitated by suppliers like South Delhi Pharma and Medvitaz Pharma

• Legal requirements: Valid prescription, import permit (Form 12A/12B), and the procedure date are necessary.

• Reach: Delivered across India through international courier or air freight.

✅ Bottom Line

Mulpleta is an effective, short-course, oral therapy to safely raise platelet counts for patients with chronic liver disease undergoing scheduled procedures. It significantly reduces the need for platelet transfusions. However, vigilance is critical for thrombotic risks, and it requires careful planning relative to procedure dates.