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OJJAARA (MOMELOTINIB )

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Important Guide

Momelotinib is an oral JAK1/JAK2 and ACVR1 inhibitor indicated for the treatment of myelofibrosis with anemia. It helps reduce spleen enlargement, improve disease-related symptoms, and address anemia, making it a valuable treatment option for patients with intermediate- or high-risk myelofibrosis.

Product Meta

Category MYELOFIBROSIS WITH ANEMIA

Country of Origin

India

MEDICINE APPROVED BY

DISEASE INDICATIONS

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🏷️ Brand Name

Ojjaara

🧪 Generic Name (Salt)

Momelotinib

🏭 Manufacturer

GSK (GlaxoSmithKline)

💊 Strengths

100 mg, 150 mg & 200 mg Tablets

📋 Class

Janus Kinase (JAK1/JAK2) and ACVR1 Inhibitor

🎯 Indication / Usage

Treatment of Intermediate or High-Risk Myelofibrosis
Used in adults with anemia associated with myelofibrosis
Helps manage disease symptoms and reduce spleen enlargement

⚙️ Mechanism of Action

Inhibits JAK1 and JAK2 signaling pathways
Reduces inflammatory cytokine activity
Inhibits ACVR1, which may help improve anemia by regulating hepcidin production

💉 Dosage

200 mg orally once daily
Can be taken with or without food

⚠️ Common Side Effects

Thrombocytopenia (low platelet count)
Dizziness
Fatigue
Diarrhea
Nausea
Increased risk of infections

🚨 Precautions

Monitor complete blood counts regularly
Assess liver function during treatment
Monitor for infections and bleeding
Use effective contraception during treatment
Inform physician about all concomitant medications

This content has been reviewed by a Medical Doctor.

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